Folding of the RNA recognition motif (RRM) domains of the amyotrophic lateral sclerosis (ALS)-linked protein TDP-43 reveals an intermediate state
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The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesTDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNAStructural basis for mutation-induced destabilization of profilin 1 in ALS.Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates.TDP-43 loss of cellular function through aggregation requires additional structural determinants beyond its C-terminal Q/N prion-like domainA molecular mechanism realizing sequence-specific recognition of nucleic acids by TDP-43.An Amyloid-Like Pathological Conformation of TDP-43 Is Stabilized by Hypercooperative Hydrogen Bonds.A method for the unbiased and efficient segmental labelling of RNA-binding proteins for structure and biophysicsComparative analysis of thermal unfolding simulations of RNA recognition motifs (RRMs) of TAR DNA-binding protein 43 (TDP-43).Structural Rearrangement upon Fragmentation of the Stability Core of the ALS-Linked Protein TDP-43.TDP-43 self-interaction is modulated by redox-active compounds Auranofin, Chelerythrine and Riluzole.The proteinopathy of D169G and K263E mutants at the RNA Recognition Motif (RRM) domain of tar DNA-binding protein (tdp43) causing neurological disorders: A computational study.The RNA-Recognition Motifs of TAR DNA-Binding Protein 43 May Play a Role in the Aberrant Self-Assembly of the Protein
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Folding of the RNA recognition motif (RRM) domains of the amyotrophic lateral sclerosis (ALS)-linked protein TDP-43 reveals an intermediate state
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 04 February 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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Folding of the RNA recognition ...... reveals an intermediate state
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Folding of the RNA recognition motif
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Folding of the RNA recognition ...... reveals an intermediate state
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Folding of the RNA recognition motif
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Folding of the RNA recognition ...... reveals an intermediate state
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Folding of the RNA recognition motif
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P2093
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P1476
Folding of the RNA recognition ...... reveals an intermediate state
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Brian C Mackness
C Robert Matthews
Jill A Zitzewitz
Meme T Tran
Shannan P McClain
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P304
P356
10.1074/JBC.M113.542779
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P577
2014-02-04T00:00:00Z