Structural basis for mutation-induced destabilization of profilin 1 in ALS.
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Structural, Functional, and Immunological Characterization of Profilin Panallergens Amb a 8, Art v 4, and Bet v 2.Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity.Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia ContinuumSpinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS.Profilin 1 with the amyotrophic lateral sclerosis associated mutation T109M displays unaltered actin binding and does not affect the actin cytoskeleton.Profilin1 biology and its mutation, actin(g) in disease.The Actin Cytoskeleton in SMA and ALS: How Does It Contribute to Motoneuron Degeneration?Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation.Profilin Directly Promotes Microtubule Growth through Residues Mutated in Amyotrophic Lateral Sclerosis.The roles of intrinsic disorder-based liquid-liquid phase transitions in the "Dr. Jekyll-Mr. Hyde" behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease.A Drosophila model of ALS reveals a partial loss of function of causative human PFN1 mutants.CHCHD10 Pro34Ser is not a highly penetrant pathogenic variant for amyotrophic lateral sclerosis and frontotemporal dementia.
P2860
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P2860
Structural basis for mutation-induced destabilization of profilin 1 in ALS.
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2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
@zh-hk
2015年論文
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2015年論文
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2015年论文
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2015年论文
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2015年论文
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name
Structural basis for mutation-induced destabilization of profilin 1 in ALS.
@ast
Structural basis for mutation-induced destabilization of profilin 1 in ALS.
@en
type
label
Structural basis for mutation-induced destabilization of profilin 1 in ALS.
@ast
Structural basis for mutation-induced destabilization of profilin 1 in ALS.
@en
prefLabel
Structural basis for mutation-induced destabilization of profilin 1 in ALS.
@ast
Structural basis for mutation-induced destabilization of profilin 1 in ALS.
@en
P2093
P2860
P356
P1476
Structural basis for mutation-induced destabilization of profilin 1 in ALS.
@en
P2093
Bruce L Goode
Celia A Schiffer
Jill A Zitzewitz
John E Landers
Maeve Tischbein
Shivender M Shandilya
Silvia Jansen
Tania V Silvas
P2860
P304
P356
10.1073/PNAS.1424108112
P407
P577
2015-06-08T00:00:00Z