The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.
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The many faces of hematopoietic stem cell heterogeneityNotch signaling in the malignant bone marrow microenvironment: implications for a niche-based model of oncogenesis.Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cellsHuman stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.The influence of miR-34a expression on stemness and cytotoxic susceptibility of breast cancer stem cellsActivation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer.Transcriptional regulation of early T-cell development in the thymus.Endothelial-to-hematopoietic transition: Notch-ing vessels into blood.Gain-of-function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells.Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response.Developing HSCs become Notch independent by the end of maturation in the AGM region.Engineered Murine HSCs Reconstitute Multi-lineage Hematopoiesis and Adaptive Immunity.The Varied Roles of Notch in Cancer.C-terminal deletion of NOTCH1 intracellular domain (N1ICD) increases its stability but does not amplify and recapitulate N1ICD-dependent signallingThe common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia.Bepridil exhibits anti-leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia.Inhibition of TGF-β and NOTCH Signaling by Cutaneous Papillomaviruses.NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.NOTCH1 Is Aberrantly Activated in Chronic Lymphocytic Leukemia Hematopoietic Stem Cells.
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P2860
The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.
description
article científic
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article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on March 2014
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The Notch1 transcriptional act ...... etal hematopoietic stem cells.
@en
The Notch1 transcriptional act ...... etal hematopoietic stem cells.
@nl
type
label
The Notch1 transcriptional act ...... etal hematopoietic stem cells.
@en
The Notch1 transcriptional act ...... etal hematopoietic stem cells.
@nl
prefLabel
The Notch1 transcriptional act ...... etal hematopoietic stem cells.
@en
The Notch1 transcriptional act ...... etal hematopoietic stem cells.
@nl
P2093
P2860
P356
P1433
P1476
The Notch1 transcriptional act ...... fetal hematopoietic stem cells
@en
P2093
Antony W Wood
Dawson M Gerhardt
Gerald B Wertheim
John W Tobias
Jon C Aster
Jonathan A Epstein
Kostandin V Pajcini
Michael J Chen
P2860
P304
P356
10.1101/GAD.227496.113
P577
2014-03-01T00:00:00Z