Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
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Comparative analysis of viral RNA signatures on different RIG-I-like receptorsPicornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virusSensing viral RNAs by Dicer/RIG-I like ATPases across speciesMDA5 and LGP2: accomplices and antagonists of antiviral signal transductionRecent insights into the evolution of innate viral sensing in animalsLGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signalingFoot-and-mouth disease virus infection inhibits LGP2 protein expression to exaggerate inflammatory response and promote viral replication.The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly.In vivo ligands of MDA5 and RIG-I in measles virus-infected cells.MDA5-filament, dynamics and disease.An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune responseStructural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrewIntracellular detection of viral nucleic acids.Foot-and-Mouth Disease Virus Viroporin 2B Antagonizes RIG-I-Mediated Antiviral Effects by Inhibition of Its Protein Expression.Inactivation of the type I interferon pathway reveals long double-stranded RNA-mediated RNA interference in mammalian cells.Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling.Interferon regulatory factor 3 in adaptive immune responses.Antiviral RNA recognition and assembly by RLR family innate immune sensors.Pattern Recognition and Signaling Mechanisms of RIG-I and MDA5Emerging complexity and new roles for the RIG-I-like receptors in innate antiviral immunity.Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) in fish: current knowledge and future perspectives.Quantitative microspectroscopic imaging reveals viral and cellular RNA helicase interactions in live cells.Endogenous Retroelements and the Host Innate Immune Sensors.Paramyxovirus V protein interaction with the antiviral sensor LGP2 disrupts MDA5 signaling enhancement but is not relevant to LGP2-mediated RLR signaling inhibitionMolecular Mechanisms of Foot-and-Mouth Disease Virus Targeting the Host Antiviral Response.RNA-virus proteases counteracting host innate immunity.Non-encapsidated 5' copy-back defective-interfering genomes produced by recombinant measles viruses are recognized by RIG-I and LGP2 but not MDA5.Discrimination of Self and Non-Self Ribonucleic Acids.Laboratory of genetics and physiology 2 (LGP2) plays an essential role in hepatitis C virus infection-induced interferon responses.Alternative Splicing Transcripts of Zebrafish LGP2 Gene Differentially Contribute to IFN Antiviral Response.The RIG-I-like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells.RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling.DHX29 functions as an RNA co-sensor for MDA5-mediated EMCV-specific antiviral immunity.RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virusInnate Immune Detection of Cardioviruses and Viral Disruption of Interferon SignalingInnate immune sensor laboratory of genetics and physiology 2 suppresses tumor cell growth and functions as a prognostic marker in neuroblastoma
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Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
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article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 18 February 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
@en
Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
@nl
type
label
Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
@en
Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
@nl
prefLabel
Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
@en
Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
@nl
P2093
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P356
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P1476
Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
@en
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Annabel Borg
Delphine Goubau
Nik Matthews
Safia Deddouche
P2860
P304
P356
10.7554/ELIFE.01535
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P50
P577
2014-02-18T00:00:00Z