Localization-dependent and -independent roles of SLX4 in regulating telomeres.
about
Nucleases in homologous recombination as targets for cancer therapyNucleo-cytoplasmic shuttling of the endonuclease ankyrin repeats and LEM domain-containing protein 1 (Ankle1) is mediated by canonical nuclear export- and nuclear import signalsSlx4 and Rtt107 control checkpoint signalling and DNA resection at double-strand breaks.Mgm101: A double-duty Rad52-like protein.Conditional genetic interactions of RTT107, SLX4, and HRQ1 reveal dynamic networks upon DNA damage in S. cerevisiae.The basic N-terminal domain of TRF2 limits recombination endonuclease action at human telomeresNoncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediatesComplex interactions between the DNA-damage response and mammalian telomeres.TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions.Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex.Fanconi anemia proteins in telomere maintenance.TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End ProtectionQuality control of homologous recombination.Nuclease delivery: versatile functions of SLX4/FANCP in genome maintenance.Fanconi Anemia: A DNA repair disorder characterized by accelerated decline of the hematopoietic stem cell compartment and other features of aging.DNA Replication Origins and Fork Progression at Mammalian TelomeresUbiquitination and SUMOylation in Telomere Maintenance and Dysfunction.Distinct functional roles for the two SLX4 ubiquitin-binding UBZ domains mutated in Fanconi anemia.Expression of Telomere-Associated Proteins is Interdependent to Stabilize Native Telomere Structure and Telomere Dysfunction by G-Quadruplex Ligand Causes TERRA Upregulation.BLM and SLX4 play opposing roles in recombination-dependent replication at human telomeres.The Structure-Specific Endonucleases MUS81 and SEND1 Are Essential for Telomere Stability in Arabidopsis.Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism.
P2860
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P2860
Localization-dependent and -independent roles of SLX4 in regulating telomeres.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 29 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Localization-dependent and -independent roles of SLX4 in regulating telomeres.
@en
Localization-dependent and -independent roles of SLX4 in regulating telomeres.
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type
label
Localization-dependent and -independent roles of SLX4 in regulating telomeres.
@en
Localization-dependent and -independent roles of SLX4 in regulating telomeres.
@nl
prefLabel
Localization-dependent and -independent roles of SLX4 in regulating telomeres.
@en
Localization-dependent and -independent roles of SLX4 in regulating telomeres.
@nl
P2093
P2860
P1433
P1476
Localization-dependent and -independent roles of SLX4 in regulating telomeres.
@en
P2093
Dennis Castor
Jamie S J Wilson
John Rouse
Rachel Toth
P2860
P304
P356
10.1016/J.CELREP.2013.07.033
P577
2013-08-29T00:00:00Z