Mutation in the γ2-subunit of AMP-activated protein kinase stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage.
about
A novel PRKAG2 mutation in a Chinese family with cardiac hypertrophy and ventricular pre-excitationIncreased Postnatal Cardiac Hyperplasia Precedes Cardiomyocyte Hypertrophy in a Model of Hypertrophic Cardiomyopathy.Transgenic knockdown of cardiac sodium/glucose cotransporter 1 (SGLT1) attenuates PRKAG2 cardiomyopathy, whereas transgenic overexpression of cardiac SGLT1 causes pathologic hypertrophy and dysfunction in mice.AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism.Adiponectin enhances bone marrow mesenchymal stem cell resistance to flow shear stress through AMP-activated protein kinase signalingIntegrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.Profiling analysis of long non-coding RNAs in early postnatal mouse hearts.AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease.The role of post-translational modifications in acute and chronic cardiovascular disease.Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy.Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensingClinical Spectrum of PRKAG2 Syndrome.A novel, de novo mutation in the PRKAG2 gene: infantile-onset phenotype and the signaling pathway involved.PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain.Animal Models to Study AMPK.Targeting the energy guardian AMPK: another avenue for treating cardiomyopathy?Genetics and Genomics of Single-Gene Cardiovascular Diseases: Common Hereditary Cardiomyopathies as Prototypes of Single-Gene Disorders.AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.Metabolic remodelling in hypertrophied and failing myocardium: a review.Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice.Effect of ligustilide on Ang II-induced hypertrophy in cardiomyocytes and the potential mechanismsInhibition of AMPK expression in skeletal muscle by systemic inflammation in COPD rats.Activation of γ2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury.PRKAG2 mutations presenting in infancy.Storage diseases with hypertrophic cardiomyopathy phenotype
P2860
Q33729245-4F3A1B65-536D-4D64-8C7F-D7582414D68FQ33795234-E7D738AD-03E8-4ED7-8B94-4301AD92BB0AQ35026241-0C21390B-9B11-4727-BE58-39E9B9BE3298Q36048973-F8D9E97E-B6C6-426D-B642-8F8B79858774Q37096440-F26B4D67-0B0A-448F-BD06-9573C924C136Q37540514-BC4C839C-D15A-44F0-95FC-A0D6AB40BF07Q37684100-5C0E20C9-DB07-4381-BBEE-E6CC1B5BC1DFQ38211516-D22DD0F7-C862-4A08-83DA-8B373796F940Q38222880-16858CA6-8F87-4B9D-BE0D-22DAEA97271AQ38399909-BBCA7932-7DD2-4CB2-8998-1D6D6B77F4CBQ38430525-3A148880-F7C7-452F-AC57-79215EE1D114Q38686608-B11D3DC3-1801-4660-AFCD-94447430F721Q38760684-572FB620-BBB2-4761-955B-AB6875BE287FQ38908127-A4DB6E30-1EDB-48B7-922C-9AA7B927FF26Q38998435-1267AF9E-FB74-4C64-834E-8CC91D807091Q38999231-133399F8-9BF4-49B0-ABAD-A2BDCEEDCD20Q39050554-09B7698D-46C8-4CB9-B867-E11FD576249EQ39331294-C2530848-C9AE-448D-89CE-2E2AC750CB35Q39395331-0E59B527-9CA6-4B0C-9D79-56809877FBA3Q39398110-336BEEDE-B30C-4903-A3C5-854EBDC7C288Q40816587-C25AFD9D-663F-420E-9827-8F88D0B7E84BQ42603766-5667F4A2-8D5D-46C3-B945-64579571DC24Q47914394-00D32CD1-C318-4EC3-B336-A4CC407CD9BAQ47961939-221B964A-0838-40FD-90E2-C76737301D81Q58565558-909A06C5-46BB-4537-A852-FFCAD314651D
P2860
Mutation in the γ2-subunit of AMP-activated protein kinase stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 06 February 2014
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Mutation in the γ2-subunit of ...... dependent of glycogen storage.
@en
Mutation in the γ2-subunit of ...... dependent of glycogen storage.
@nl
type
label
Mutation in the γ2-subunit of ...... dependent of glycogen storage.
@en
Mutation in the γ2-subunit of ...... dependent of glycogen storage.
@nl
prefLabel
Mutation in the γ2-subunit of ...... dependent of glycogen storage.
@en
Mutation in the γ2-subunit of ...... dependent of glycogen storage.
@nl
P2093
P2860
P50
P1433
P1476
Mutation in the γ2-subunit of ...... ndependent of glycogen storage
@en
P2093
Guohua Gong
Kei Sakamoto
Lorena Garcia-Menendez
Stephen C Kolwicz
Yu-Ying Yang
P2860
P304
P356
10.1161/CIRCRESAHA.114.302364
P577
2014-02-06T00:00:00Z