Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals
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Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathwayTamoxifen Resistance: Emerging Molecular TargetsThe hedgehog pathway in triple-negative breast cancerTargeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI InhibitorsRoles for Hedgehog signaling in adult organ homeostasis and repairCooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapyAberrant activation of the hedgehog signaling pathway in malignant hematological neoplasmsContext-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapySOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties.Hedgehog signaling and the Gli code in stem cells, cancer, and metastasesComputational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factorsActivation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regenerationGli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossificationTargeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration.Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception.GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent stateTargeting Hedgehog--a cancer stem cell pathwayMutations in fam20b and xylt1 reveal that cartilage matrix controls timing of endochondral ossification by inhibiting chondrocyte maturationThe transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner.NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53.Genetic variations in the sonic hedgehog pathway affect clinical outcomes in non-muscle-invasive bladder cancerFrequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.A new role for Hedgehogs in juxtacrine signaling.Clinicopathological correlates of Gli1 expression in a population-based cohort of patients with newly diagnosed bladder cancerExpression of the glioma-associated oncogene homolog 1 (gli1) in advanced serous ovarian cancer is associated with unfavorable overall survival.Gli1 mediates lung cancer cell proliferation and Sonic Hedgehog-dependent mesenchymal cell activation.Personalized colon cancer care in 2010.Sonic hedgehog signaling pathway supports cancer cell growth during cancer radiotherapy.Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1Gli1 enhances migration and invasion via up-regulation of MMP-11 and promotes metastasis in ERα negative breast cancer cell lines.Significance of glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway.Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cellsHeterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration.WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation.Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei.The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened.Combination of cyclopamine and tamoxifen promotes survival and migration of mcf-7 breast cancer cells--interaction of hedgehog-gli and estrogen receptor signaling pathways.Synergistic inhibition of colon carcinoma cell growth by Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002.Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia.Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.
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Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 17 January 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Context-dependent regulation o ...... GEHOG and non-HEDGEHOG signals
@en
Context-dependent regulation o ...... EHOG and non-HEDGEHOG signals.
@nl
type
label
Context-dependent regulation o ...... GEHOG and non-HEDGEHOG signals
@en
Context-dependent regulation o ...... EHOG and non-HEDGEHOG signals.
@nl
prefLabel
Context-dependent regulation o ...... GEHOG and non-HEDGEHOG signals
@en
Context-dependent regulation o ...... EHOG and non-HEDGEHOG signals.
@nl
P2860
P356
P1476
Context-dependent regulation o ...... GEHOG and non-HEDGEHOG signals
@en
P2093
Ariel Ruiz I Altaba
P2860
P356
10.1093/JMCB/MJP052
P577
2010-01-17T00:00:00Z