Longikaurin A, a natural ent-kaurane, induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells.
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Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition ReactionsROS generation mediates the anti-cancer effects of WZ35 via activating JNK and ER stress apoptotic pathways in gastric cancer.Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP.Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells.Jungermannenone A and B induce ROS- and cell cycle-dependent apoptosis in prostate cancer cells in vitro.Antitumor effects of traditional Chinese medicine targeting the cellular apoptotic pathway.Longikaurin A, a natural ent-kaurane, suppresses stemness in nasopharyngeal carcinoma cells.Melatonin promotes sorafenib-induced apoptosis through synergistic activation of JNK/c-jun pathway in human hepatocellular carcinoma.Three New Cytotoxic ent-Kaurane Diterpenes from Isodon excisoides.Longikaurin E induces apoptosis of pancreatic cancer cells via modulation of the p38 and PI3K/AKT pathways by ROS.Diterpenes and Their Derivatives as Potential Anticancer Agents.Alisol B 23-acetate induces autophagic-dependent apoptosis in human colon cancer cells via ROS generation and JNK activation.Pteisolic acid G, a novel ent-kaurane diterpenoid, inhibits viability and induces apoptosis in human colorectal carcinoma cells.Diterpenoids from Isodon species: an update.Natural borneol enhances bisdemethoxycurcumin-induced cell cycle arrest in the G2/M phase through up-regulation of intracellular ROS in HepG2 cells.Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells.UBAP2L silencing inhibits cell proliferation and G2/M phase transition in breast cancer.Dysregulated expression of SKP2 and its role in hematological malignancies.Rabdocoestin B exhibits antitumor activity by inducing G2/M phase arrest and apoptosis in esophageal squamous cell carcinoma.Signaling protein signature predicts clinical outcome of non-small-cell lung cancer.Role of C-Jun N-terminal Kinase in Hepatocellular Carcinoma Development.Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer.Chelerythrine induced cell death through ROS-dependent ER stress in human prostate cancer cells.A natural ent‑kaurane diterpenoid induces antiproliferation in ovarian cancer cells via ERK1/2 regulation and inhibition of cellular migration and invasion
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P2860
Longikaurin A, a natural ent-kaurane, induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 20 March 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Longikaurin A, a natural ent-k ...... epatocellular carcinoma cells.
@en
Longikaurin A, a natural ent-k ...... epatocellular carcinoma cells.
@nl
type
label
Longikaurin A, a natural ent-k ...... epatocellular carcinoma cells.
@en
Longikaurin A, a natural ent-k ...... epatocellular carcinoma cells.
@nl
prefLabel
Longikaurin A, a natural ent-k ...... epatocellular carcinoma cells.
@en
Longikaurin A, a natural ent-k ...... epatocellular carcinoma cells.
@nl
P2093
P2860
P356
P1476
Longikaurin A, a natural ent-k ...... epatocellular carcinoma cells.
@en
P2093
P2860
P2888
P356
10.1038/CDDIS.2014.66
P577
2014-03-20T00:00:00Z
P5875
P6179
1013634085