Cognitive improvement by activation of alpha7 nicotinic acetylcholine receptors: from animal models to human pathophysiology.
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Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicologyAcute nicotine-induced tachyphylaxis is differentially manifest in the limbic systemNicotinic acetylcholine receptor ligands, a patent review (2006-2011)α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimumDifferential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in ratsα7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological PropertiesEvaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia.Fluctuations in endogenous kynurenic acid control hippocampal glutamate and memoryIntrinsically low open probability of α7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperaturesThe binding orientation of epibatidine at α7 nACh receptorsTheranostic Biomarkers for SchizophreniaActivation of functional α7-containing nAChRs in hippocampal CA1 pyramidal neurons by physiological levels of choline in the presence of PNU-120596Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.Role of alpha7 nicotinic acetylcholine receptor in calcium signaling induced by prion protein interaction with stress-inducible protein 1.Resisting the urge to smoke and craving during a smoking quit attempt on varenicline: results from a pilot fMRI study.An experimental study on (131)I-CHIBA-1001: a radioligand for α7 nicotinic acetylcholine receptors.A type-II positive allosteric modulator of α7 nAChRs reduces brain injury and improves neurological function after focal cerebral ischemia in rats.Evaluation of spinal cord motor function in Alzheimer's disease using electrophysiological techniques indicates association of acetylcholine receptors with the disease.High therapeutic potential of positive allosteric modulation of α7 nAChRs in a rat model of traumatic brain injury: proof-of-conceptPositive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Cancer 'survivor-care': I. the α7 nAChR as potential target for chemotherapy-related cognitive impairment.Design and Synthesis of Nicotinic Acetylcholine Receptor Antagonists and their Effect on Cognitive Impairment.Nicotinic Acetylcholine Receptors Sensitize a MAPK-linked Toxicity Pathway on Prolonged Exposure to β-Amyloid.Neuroprotective effect of cellular prion protein (PrPC) is related with activation of alpha7 nicotinic acetylcholine receptor (α7nAchR)-mediated autophagy flux.Effects of α7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models.The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models.Activation of α7 nicotinic acetylcholine receptors increases intracellular cAMP levels via activation of AC1 in hippocampal neurons.A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer's disease.Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT₁a receptor antagonist.The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptors in MiceIn vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model.A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia.Targeting of α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia and the Use of Auditory Sensory Gating as a Translational BiomarkerStoichiometry for activation of neuronal α7 nicotinic receptors.Human brain imaging of α7 nAChR with [(18)F]ASEM: a new PET radiotracer for neuropsychiatry and determination of drug occupancyPrefrontal cortical network connections: key site of vulnerability in stress and schizophrenia.Schizophrenia as a disorder of too little dopamine: implications for symptoms and treatment.α7 Nicotinic receptor modulators for cognitive deficits in schizophrenia and Alzheimer's disease.The vagal innervation of the gut and immune homeostasisNeuronal AChE splice variants and their non-hydrolytic functions: redefining a target of AChE inhibitors?
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Cognitive improvement by activation of alpha7 nicotinic acetylcholine receptors: from animal models to human pathophysiology.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2010
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Cognitive improvement by activ ...... dels to human pathophysiology.
@en
Cognitive improvement by activ ...... dels to human pathophysiology.
@nl
type
label
Cognitive improvement by activ ...... dels to human pathophysiology.
@en
Cognitive improvement by activ ...... dels to human pathophysiology.
@nl
prefLabel
Cognitive improvement by activ ...... dels to human pathophysiology.
@en
Cognitive improvement by activ ...... dels to human pathophysiology.
@nl
P2093
P1476
Cognitive improvement by activ ...... dels to human pathophysiology.
@en
P2093
Daniel B Timmerman
Henrik H Hansen
Jens D Mikkelsen
Morten S Thomsen
P304
P356
10.2174/138161210790170094
P577
2010-01-01T00:00:00Z