RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
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In a Class of Their Own - RXFP1 and RXFP2 are Unique Members of the LGR FamilyLGR4 and Its Role in Intestinal Protection and Energy MetabolismThe biology of IQGAP proteins: beyond the cytoskeletonLGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea.Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions.IQGAPs choreograph cellular signaling from the membrane to the nucleusThe Overexpression of IQGAP1 and β-Catenin Is Associated with Tumor Progression in Hepatocellular Carcinoma In Vitro and In Vivo.Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness.IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomesPhenotypic and Molecular Alterations in the Mammary Tissue of R-Spondin1 Knock-Out Mice during Pregnancy.Rationalising the role of Keratin 9 as a biomarker for Alzheimer's disease.Identification of DPY19L3 as the C-mannosyltransferase of R-spondin1 in human cellsCAF-like state in primary skin fibroblasts with constitutional BRCA1 epimutation sheds new light on tumor suppressor deficiency-related changes in healthy tissue.IQGAP1 is a phosphoinositide effector and kinase scaffoldMesonephric Cell Migration into the Gonads and Vascularization Are Processes Crucial for Testis Development.R-spondin 2 promotes proliferation and migration via the Wnt/β-catenin pathway in human hepatocellular carcinoma.LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway.Establishment of a tagged variant of Lgr4 receptor suitable for functional and expression studies in the mouse.The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2.Wnt, RSPO and Hippo Signalling in the Intestine and Intestinal Stem Cells.LGR4 modulates breast cancer initiation, metastasis, and cancer stem cells.Blockade of LGR4 inhibits proliferation and odonto/osteogenic differentiation of stem cells from apical papillae.Transcriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance.Novel Genetic Variants Associated with Lumbar Spondylosis in Koreans : A Genome-Wide Association Study.Downregulation of IQGAP2 Correlates with Prostate Cancer Recurrence and MetastasisTargeting Focal Adhesion Kinase Using Inhibitors of Protein-Protein Interactions
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RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 17 March 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
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RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
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RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
@en
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
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RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
@en
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.
@nl
P2093
P2860
P356
P1476
RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling
@en
P2093
Anthony Thomas
Qingyun Liu
P2860
P304
P356
10.1073/PNAS.1323106111
P407
P577
2014-03-17T00:00:00Z