Checkpoints in the progression of autoimmune disease: lessons from diabetes models.
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Bioluminescence imaging reveals dynamics of beta cell loss in the non-obese diabetic (NOD) mouse modelType 1 diabetes: translating mechanistic observations into effective clinical outcomesThe role of the PD-1 pathway in autoimmunity and peripheral toleranceInhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseasesDeath pathways in T cell homeostasis and their role in autoimmune diabetes.RasGAP-derived fragment N increases the resistance of beta cells towards apoptosis in NOD mice and delays the progression from mild to overt diabetes.Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development.Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes.Tumor necrosis factor-alpha and the progression of diabetes in non-obese diabetic mice.Autoaggression and tumor rejection: it takes more than self-specific T-cell activation.Interferon-gamma impacts at multiple points during the progression of autoimmune diabetesTargeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes.Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organsChanges in function of antigen-specific lymphocytes correlating with progression towards diabetes in a transgenic model.Grafts of supplementary thymuses injected with allogeneic pancreatic islets protect nonobese diabetic mice against diabetes.Maternal obesity exacerbates insulitis and type 1 diabetes in non-obese diabetic miceActivation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets.Cutting edge: merocytic dendritic cells break T cell tolerance to beta cell antigens in nonobese diabetic mouse diabetes.Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background.Immunosuppression without immunosuppression? How to be a tolerant individual in a dangerous world.Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cellsMurine animal models for preclinical islet transplantation: No model fits all (research purposes).Transgenic models of autoimmune disease.The enemy within: keeping self-reactive T cells at bay in the periphery.Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2.Interleukin-10+ regulatory B cells arise within antigen-experienced CD40+ B cells to maintain tolerance to islet autoantigensCCR4-bearing T cells participate in autoimmune diabetes.Population dynamics of islet-infiltrating cells in autoimmune diabetes.Spectratyping analysis of the islet-reactive T cell repertoire in diabetic NOD Igμ(null) mice after polyclonal B cell reconstitutionProgressive erosion of β-cell function precedes the onset of hyperglycemia in the NOD mouse model of type 1 diabetes.Beta cell MHC class I is a late requirement for diabetesT cell-driven initiation and propagation of autoimmune diabetesNeuroendocrine immuno-ontogeny of the pathogenesis of autoimmune disease in the nonobese diabetic (NOD) mouse.Beta cell apoptosis in T cell-mediated autoimmune diabetes.Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity.Gamma c cytokines condition the progressive differentiation of CD4+ T cellsThe role of hyaluronan and the extracellular matrix in islet inflammation and immune regulation.Tissue expression of PD-L1 mediates peripheral T cell tolerance.Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD miceImmunotherapy for the prevention and treatment of type 1 diabetes.
P2860
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P2860
Checkpoints in the progression of autoimmune disease: lessons from diabetes models.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Checkpoints in the progression of autoimmune disease: lessons from diabetes models.
@en
Checkpoints in the progression of autoimmune disease: lessons from diabetes models.
@nl
type
label
Checkpoints in the progression of autoimmune disease: lessons from diabetes models.
@en
Checkpoints in the progression of autoimmune disease: lessons from diabetes models.
@nl
prefLabel
Checkpoints in the progression of autoimmune disease: lessons from diabetes models.
@en
Checkpoints in the progression of autoimmune disease: lessons from diabetes models.
@nl
P2093
P2860
P356
P1476
Checkpoints in the progression of autoimmune disease: lessons from diabetes models.
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.6.2260
P407
P577
1996-03-01T00:00:00Z