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mTOR's role in ageing: protein synthesis or autophagy?

mTOR's role in ageing: protein synthesis or autophagy?

http://www.wikidata.org/entity/Q37693034

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Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription MicroRNA-Based Linkage between Aging and Cancer: from Epigenetics View Point Current therapeutic developments in atrophic age-related macular degeneration Dysregulation of skeletal muscle protein metabolism by alcohol Autophagy and apoptosis in liver injury Mechanisms of mitochondria and autophagy crosstalk Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence Testing the Effects of DL-Alpha-Tocopherol Supplementation on Oxidative Damage, Total Antioxidant Protection and the Sex-Specific Responses of Reproductive Effort and Lifespan to Dietary Manipulation in Australian Field Crickets (Teleogryllus commod Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation.Cardio-Oncology: Cancer Therapy-related Cardiovascular Complications in a Molecular Targeted Era: New Concepts and Perspectives.Why human lifespan is rapidly increasing: solving "longevity riddle" with "revealed-slow-aging" hypothesis.The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease.Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level.CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?Berberine suppresses gero-conversion from cell cycle arrest to senescence.TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.Selective anti-cancer agents as anti-aging drugs Gene expression patterns underlying parasite-induced alterations in host behaviour and life history.Metformin and sex: Why suppression of aging may be harmful to young male mice.Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae.Aging and gastrointestinal neuromuscular function: insights from within and outside the gut.Bolus ingestion of individual branched-chain amino acids alters plasma amino acid profiles in young healthy men Characterization of hibernating ribosomes in mammalian cells.Assessment of the effect of laser irradiations at different wavelengths (660, 810, 980, and 1064 nm) on autophagy in a rat model of mucositis.Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs.Hormesis does not make sense except in the light of TOR-driven aging.Perspectives of Targeting mTORC1-S6K1 in Cardiovascular Aging Molecular damage in cancer: an argument for mTOR-driven aging Exceptional longevity is associated with decreased reproduction.Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy mTOR coordinates protein synthesis, mitochondrial activity and proliferation.The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease Quantitation of underivatized branched-chain amino acids in sport nutritional supplements by capillary electrophoresis with direct or indirect UV absorbance detection MTOR signaling and ubiquitin-proteosome gene expression in the preservation of fat free mass following high protein, calorie restricted weight loss.Aging and reprogramming: a two-way street.Chronic cerebral hypoperfusion enhances Tau hyperphosphorylation and reduces autophagy in Alzheimer's disease mice.mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects.

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mTOR's role in ageing: protein synthesis or autophagy?

http://www.wikidata.org/entity/Q37693034

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 20 July 2009

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

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name

mTOR's role in ageing: protein synthesis or autophagy?

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mTOR's role in ageing: protein synthesis or autophagy?

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type

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mTOR's role in ageing: protein synthesis or autophagy?

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mTOR's role in ageing: protein synthesis or autophagy?

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mTOR's role in ageing: protein synthesis or autophagy?

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mTOR's role in ageing: protein synthesis or autophagy?

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mTOR's role in ageing: protein synthesis or autophagy?

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Andreas Wyttenbach

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Christopher G Proud

http://www.w3.org/2001/XMLSchema#string

Sarah L Hands

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Creative Commons Attribution 2.5 Unported

P2860

Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9

Ultraviolet-induced phosphorylation of p70(S6k) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase c

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

Regulation of autophagy by cytoplasmic p53

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586-597

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scholarly article

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10.18632/AGING.100070

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7

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1

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2009-07-20T00:00:00Z

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20157541

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2806042

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