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Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulationTyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cellsExpression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression systemIncreased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinaseCloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cellsActivation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signalingEps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signalsInteractions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptorA pharmacological map of the PI3-K family defines a role for p110alpha in insulin signalingDirect association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 betaCloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinaseThe PI3K/AKT Pathway and Renal Cell CarcinomaPhospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKEThe COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signalingDirect association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinaseRegulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunitTyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signalingProtein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transportArp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cellsThe adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblastsThe erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potencyA complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment.Structure of 85 kDa subunit of human phosphatidylinositol 3-kinase analyzed by using monoclonal antibodies.Mutations in the SH3 domain of the src oncogene which decrease association of phosphatidylinositol 3'-kinase activity with pp60v-src and alter cellular morphology.Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinasePolarization of chemoattractant receptor signaling during neutrophil chemotaxisInteraction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptorsIGF-1 receptor as an alternative receptor for metabolic signaling in insulin receptor-deficient muscle cells.The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growthHIV gp41 engages gC1qR on CD4+ T cells to induce the expression of an NK ligand through the PIP3/H2O2 pathway.Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activityInsulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant miceActivation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor on human thymocytes.Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.Natural biology of polyomavirus middle T antigen.PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice.A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 1990
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Activation of phosphatidylinositol 3-kinase by insulin.
@en
Activation of phosphatidylinositol 3-kinase by insulin.
@nl
type
label
Activation of phosphatidylinositol 3-kinase by insulin.
@en
Activation of phosphatidylinositol 3-kinase by insulin.
@nl
prefLabel
Activation of phosphatidylinositol 3-kinase by insulin.
@en
Activation of phosphatidylinositol 3-kinase by insulin.
@nl
P2093
P2860
P356
P1476
Activation of phosphatidylinositol 3-kinase by insulin.
@en
P2093
N B Ruderman
R Kapeller
P2860
P304
P356
10.1073/PNAS.87.4.1411
P407
P577
1990-02-01T00:00:00Z