Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses. - Wikidata - awgldk - TriplyDB

Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses.

Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses.

http://www.wikidata.org/entity/Q37698081

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Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nanoparticle (secondary) genotoxicity Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™)Evaluation of the automated MicroFlow® and Metafer™ platforms for high-throughput micronucleus scoring and dose response analysis in human lymphoblastoid TK6 cells.Micronucleus formation in human keratinocytes is dependent on radiation quality and tissue architecture.Acute dosing and p53-deficiency promote cellular sensitivity to DNA methylating agents.Human mesenchymal stem cells as a novel platform for simultaneous evaluation of cytotoxicity and genotoxicity of pharmaceuticals.An integrative test strategy for cancer hazard identification.Evaluation of the LacZ reporter assay in cryopreserved primary hepatocytes for In vitro genotoxicity testing.

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Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses.

http://www.wikidata.org/entity/Q37698081

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 27 March 2014

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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Automation and validation of m ...... lation with 2D dose responses.

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Automation and validation of m ...... lation with 2D dose responses.

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Automation and validation of m ...... lation with 2D dose responses.

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Automation and validation of m ...... lation with 2D dose responses.

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Automation and validation of m ...... lation with 2D dose responses.

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Automation and validation of m ...... elation with 2D dose responses

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J W Wills

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S Pfuhler

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P2860

Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose-response relationships, exemplified for mutagenicity data.

The in vitro micronucleus technique.

Do dose response thresholds exist for genotoxic alkylating agents?

Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance

Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure.

In vitro genotoxicity testing using the micronucleus assay in cell lines, human lymphocytes and 3D human skin models.

Recommendations, evaluation and validation of a semi-automated, fluorescent-based scoring protocol for micronucleus testing in human cells.

Influence of DNA repair on nonlinear dose-responses for mutation.

Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens.

HUMN project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures.

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165-175

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10.1093/MUTAGE/GEU011

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Katherine E Chapman

Gareth J Jenkins

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