Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose-response relationships, exemplified for mutagenicity data.
about
Molecular signaling network motifs provide a mechanistic basis for cellular threshold responsesMiniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships.Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damageA mode-of-action approach for the identification of genotoxic carcinogens.Kinetic Modeling Reveals the Roles of Reactive Oxygen Species Scavenging and DNA Repair Processes in Shaping the Dose-Response Curve of KBrO₃-Induced DNA Damage.Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic toleranceContributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents.Genotoxic mixtures and dissimilar action: concepts for prediction and assessmentCan case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?".Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses.Genotoxicity testing: moving beyond qualitative "screen and bin" approach towards characterization of dose-response and thresholds.Use of threshold and mode of action in risk assessment.Dose-response approaches for nuclear receptor-mediated modes of action for liver carcinogenicity: Results of a workshop.The use of mode of action information in risk assessment: quantitative key events/dose-response framework for modeling the dose-response for key events.Defining EMS and ENU dose-response relationships using the Pig-a mutation assay in ratsReassessment of MTBE cancer potency considering modes of action for MTBE and its metabolites.An appraisal of critical effect sizes for the benchmark dose approach to assess dose-response relationships in genetic toxicology.Phenolphthalein induces centrosome amplification and tubulin depolymerization in vitro.N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage.Genetic toxicology at the crossroads-from qualitative hazard evaluation to quantitative risk assessment.A proposal for a novel rationale for critical effect size in dose-response analysis based on a multi-endpoint in vivo study with methyl methanesulfonate.DNA repair by MGMT, but not AAG, causes a threshold in alkylation-induced colorectal carcinogenesis.Dose-Response for Multiple Biomarkers of Exposure and Genotoxic Effect Following Repeated Treatment of Rats with the Alkylating Agents, MMS and MNU.Seven benzimidazole pesticides combined at sub-threshold levels induce micronuclei in vitro.REPARATION: ribosome profiling assisted (re-)annotation of bacterial genomes.Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound.Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran.Dose-response analysis of bromate-induced DNA damage and mutagenicity is consistent with low-dose linear, nonthreshold processes.Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adult gpt-delta transgenic mice.Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement.Quantitative assessment of the dose-response of alkylating agents in DNA repair proficient and deficient ames tester strains.Evaluation of the in vivo mutagenicity of isopropyl methanesulfonate in acute and 28-day studies.Approaches for characterizing threshold dose-response relationships for DNA-damage pathways involved in carcinogenicity in vivo and micronuclei formation in vitro.Quantitative approaches for assessing dose-response relationships in genetic toxicology studies.
P2860
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P2860
Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose-response relationships, exemplified for mutagenicity data.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Statistical model to estimate ...... plified for mutagenicity data.
@ast
Statistical model to estimate ...... plified for mutagenicity data.
@en
type
label
Statistical model to estimate ...... plified for mutagenicity data.
@ast
Statistical model to estimate ...... plified for mutagenicity data.
@en
prefLabel
Statistical model to estimate ...... plified for mutagenicity data.
@ast
Statistical model to estimate ...... plified for mutagenicity data.
@en
P1433
P1476
Statistical model to estimate ...... plified for mutagenicity data.
@en
P2093
Roman W Lutz
Werner K Lutz
P304
P356
10.1016/J.MRGENTOX.2009.05.010
P407
P577
2009-05-27T00:00:00Z