Structure and expression of murine germ-line immunoglobulin epsilon heavy chain transcripts induced by interleukin 4.
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Sequences of human immunoglobulin switch regions: implications for recombination and transcriptionmRNA transcripts initiating within the human immunoglobulin mu heavy chain enhancer region contain a non-translatable exon and are extremely heterogeneous at the 5' endInterleukin 5 (IL-5) provides a signal that is required in addition to IL-4 for isotype switching to immunoglobulin (Ig) G1 and IgE.CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells.Somatic mutations in the Ig variable region genes and expression of novel Cmu-germline transcripts in a B-lymphoma cell line ("Farage") not producing Ig polypeptide chains.Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-alpha in cultured endothelial cellsHuman antibodies from transgenic mice.Use of chromatin immunoprecipitation (ChIP) to detect transcription factor binding to highly homologous promoters in chromatin isolated from unstimulated and activated primary human B cells.An antisense oligonucleotide complementary to a sequence in I gamma 2b increases gamma 2b germline transcripts, stimulates B cell DNA synthesis, and inhibits immunoglobulin secretion.Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.Independent regulation of DNA recombination and immunoglobulin (Ig) secretion during isotype switching to IgG1 and IgECharacterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.Intrinsic transcriptional heterogeneity in B cells controls early class switching to IgE.Transcriptional regulatory elements stimulate recombination in extrachromosomal substrates carrying immunoglobulin switch-region sequencesS region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.TRIF signaling is essential for TLR4-driven IgE class switching.Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts.T cell receptor-V beta repertoire in allergen-specific sensitization and increased airway responsiveness.CREB/ATF proteins enhance the basal and CD154- and IL-4-induced transcriptional activity of the human Igamma1 proximal promoter.A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production.
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P2860
Structure and expression of murine germ-line immunoglobulin epsilon heavy chain transcripts induced by interleukin 4.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 1990
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Structure and expression of mu ...... ipts induced by interleukin 4.
@en
Structure and expression of mu ...... ipts induced by interleukin 4.
@nl
type
label
Structure and expression of mu ...... ipts induced by interleukin 4.
@en
Structure and expression of mu ...... ipts induced by interleukin 4.
@nl
prefLabel
Structure and expression of mu ...... ipts induced by interleukin 4.
@en
Structure and expression of mu ...... ipts induced by interleukin 4.
@nl
P2860
P356
P1476
Structure and expression of mu ...... ipts induced by interleukin 4.
@en
P2093
Gerondakis S
P2860
P304
P356
10.1073/PNAS.87.4.1581
P407
P577
1990-02-01T00:00:00Z