A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.
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Related Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationRad51 expression and localization in B cells carrying out class switch recombinationT-bet regulates IgG class switching and pathogenic autoantibody productionThe transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cellsAID and Apobec3G haphazard deamination and mutational diversityThe ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kappaB/Rel proteinsRegulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Strand specificity in the transcriptional targeting of recombination at immunoglobulin switch sequences.The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombinationHistone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination.The connection between transcription and genomic instability.Isolation of differentially expressed genes upon immunoglobulin class switching by a subtractive hybridization method using uracil DNA glycosylase.The AID-induced DNA damage response in chromatin.Sequences affecting the V(D)J recombinational activity of the IgH intronic enhancer in a transgenic substrate.Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Clonal variants of hybridoma cells that switch isotype at a high frequencyAlpha2p controls donor preference during mating type interconversion in yeast by inactivating a recombinational enhancer of chromosome IIINonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genesNucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1.Three-dimensional architecture of the IgH locus facilitates class switch recombination.Replacement of Igamma3 germ-line promoter by Igamma1 inhibits class-switch recombination to IgG3.Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cellsCharacterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-kappa B/p50.Immunoglobulin switch transcript production in vivo related to the site and time of antigen-specific B cell activation.Evidence for class-specific factors in immunoglobulin isotype switchingQuantitative regulation of class switch recombination by switch region transcription.H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutationVisualization of the genesis and fate of isotype-switched B cells during a primary immune responseATM is required for efficient recombination between immunoglobulin switch regions.Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase.T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switchingClass switching in B cells lacking 3' immunoglobulin heavy chain enhancers.Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regionsRegulation of AID, the B-cell genome mutator.Activation of NF-kappaB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cgamma1 promoter.Regulation and targeting of recombination in extrachromosomal substrates carrying immunoglobulin switch region sequencesAnalysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locusFifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases
P2860
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P2860
A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
A selective defect in IgG2b sw ...... I gamma 2b promoter and exon.
@en
type
label
A selective defect in IgG2b sw ...... I gamma 2b promoter and exon.
@en
prefLabel
A selective defect in IgG2b sw ...... I gamma 2b promoter and exon.
@en
P2093
P2860
P1433
P1476
A selective defect in IgG2b sw ...... I gamma 2b promoter and exon.
@en
P2093
P2860
P304
P407
P577
1993-09-01T00:00:00Z