An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae.
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Trypanothione overproduction and resistance to antimonials and arsenicals in LeishmaniaPhysiological consequences of drug resistance in Leishmania and their relevance for chemotherapyPathways of As(III) detoxification in Saccharomyces cerevisiae.Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovaniHomologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegansMolecular mechanisms of drug resistance in natural Leishmania populations vary with genetic backgroundRole of efflux pumps and intracellular thiols in natural antimony resistant isolates of Leishmania donovaniDrug resistance in natural isolates of Leishmania donovani s.l. promastigotes is dependent of Pgp170 expressionSpecies-specific antimonial sensitivity in Leishmania is driven by post-transcriptional regulation of AQP1Drug resistance in eukaryotic microorganisms.The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic.Visceral leishmaniasis and arsenic: an ancient poison contributing to antimonial treatment failure in the Indian subcontinent?Biochemical and molecular mechanisms of drug resistance in parasites.The Saccharomyces cerevisiae ACR3 gene encodes a putative membrane protein involved in arsenite transport.Molecular biological applications in the diagnosis and control of leishmaniasis and parasite identification.Use of antimony in the treatment of leishmaniasis: current status and future directions.Antimony resistance in leishmania, focusing on experimental research.Antimony uptake systems in the protozoan parasite Leishmania and accumulation differences in antimony-resistant parasitesGene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility.A new ABC half-transporter in Leishmania major is involved in resistance to antimony.ABC transporters involved in drug resistance in human parasites.Drug-resistant microorganisms with a higher fitness--can medicines boost pathogens?Flavone-resistant Leishmania donovani overexpresses LdMRP2 transporter in the parasite and activates host MRP2 on macrophages to circumvent the flavone-mediated cell death.Role of the ABC transporter MRPA (PGPA) in antimony resistance in Leishmania infantum axenic and intracellular amastigotes.Novel Arsenic Nanoparticles Are More Effective and Less Toxic than As (III) to Inhibit Extracellular and Intracellular Proliferation of Leishmania donovaniGene expression analysis of the mechanism of natural Sb(V) resistance in Leishmania donovani isolates from Nepal.Stage-specific activity of pentavalent antimony against Leishmania donovani axenic amastigotes.Glutathione-induced conversion of pentavalent antimony to trivalent antimony in meglumine antimoniate.Gene amplification in Leishmania tarentolae selected for resistance to sodium stibogluconate.The overexpression of genes of thiol metabolism contribute to drug resistance in clinical isolates of visceral leishmaniasis (kala azar) in India.Lower nitric oxide susceptibility of trivalent antimony-resistant amastigotes of Leishmania infantum.Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required.Reduction and coordination of arsenic in Indian mustard.The heat shock protein HSP70 and heat shock cognate protein HSC70 contribute to antimony tolerance in the protozoan parasite leishmania.Intracellular growth and metacyclogenesis defects in Trypanosoma cruzi carrying a targeted deletion of a Tc52 protein-encoding allele.Intracellular localization of the ABCC proteins of Leishmania and their role in resistance to antimonials.The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase.Assessing aquaglyceroporin gene status and expression profile in antimony-susceptible and -resistant clinical isolates of Leishmania donovani from India.Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug pentostam.Modulation in aquaglyceroporin AQP1 gene transcript levels in drug-resistant Leishmania.
P2860
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P2860
An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolae.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
An ATP-dependent As
@nl
An ATP-dependent As(III)-gluta ...... cles of Leishmania tarentolae.
@en
type
label
An ATP-dependent As
@nl
An ATP-dependent As(III)-gluta ...... cles of Leishmania tarentolae.
@en
prefLabel
An ATP-dependent As
@nl
An ATP-dependent As(III)-gluta ...... cles of Leishmania tarentolae.
@en
P2093
P2860
P356
P1476
An ATP-dependent As(III)-gluta ...... cles of Leishmania tarentolae.
@en
P2093
B Papadopoulou
J Lightbody
M Ouellette
P2860
P304
P356
10.1073/PNAS.93.5.2192
P407
P577
1996-03-01T00:00:00Z