Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule.
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Adhesion versus coreceptor function of CD4 and CD8: role of the cytoplasmic tail in coreceptor activityReconstitution of the subclass-specific expression of CD4 in thymocytes and peripheral T cells of transgenic mice: identification of a human CD4 enhancerStructural Basis of the CD8 /MHC Class I Interaction: Focused Recognition Orients CD8 to a T Cell Proximal PositionClassical and nonclassical class I major histocompatibility complex molecules exhibit subtle conformational differences that affect binding to CD8alphaalphaInterplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagementMajor histocompatibility complex class I genes of the coelacanth Latimeria chalumnaeFormation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells.Natural killer cell receptors specific for major histocompatibility complex class I molecules.The role of charge and multiple faces of the CD8 alpha/alpha homodimer in binding to major histocompatibility complex class I molecules: support for a bivalent model.Staphylococcal enterotoxin A and toxic shock syndrome toxin compete with CD4 for human major histocompatibility complex class II binding.Cross-dressed CD8α+/CD103+ dendritic cells prime CD8+ T cells following vaccination.CD8 surface levels alter the fate of alpha/beta T cell receptor-expressing thymocytes in transgenic mice.Requirement for CD8-major histocompatibility complex class I interaction in positive and negative selection of developing T cells.Distinctive polymorphism at the HLA-C locus: implications for the expression of HLA-CCorrelation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytesAn invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.Hybrid antibody mediated veto of cytotoxic T lymphocyte responses.MHC class I molecules form ternary complexes with calnexin and TAP and undergo peptide-regulated interaction with TAP via their extracellular domains.The functional binding site for the C-type lectin-like natural killer cell receptor Ly49A spans three domains of its major histocompatibility complex class I ligand.CD8 beta increases CD8 coreceptor function and participation in TCR-ligand binding.Physical and functional association of the major histocompatibility complex class I heavy chain alpha3 domain with the transporter associated with antigen processing.Comparative analysis of core amino acid residues of H-2D(b)-restricted cytotoxic T-lymphocyte recognition epitopes in simian virus 40 T antigenA heterodimer of HEB and an E12-related protein interacts with the CD4 enhancer and regulates its activity in T-cell linesCoreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC.Novel nonclassical MHC class Ib genes associated with CD8 T cell development and thymic tumors.Heterozygosity at individual amino acid sites: extremely high levels for HLA-A and -B genes.H-2 allele specificity of the NK cell C-type lectin-like MHC class I receptor Ly49A visualized by soluble Ly49A tetramer.Mutant MHC class I molecules define interactions between components of the peptide-loading complex.Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice.Glu227-->Lys substitution in the acidic loop of major histocompatibility complex class I alpha 3 domain distinguishes low avidity CD8 coreceptor and avidity-enhanced CD8 accessory functions.T Cell Receptor Binding to a pMHCII Ligand Is Kinetically Distinct from and Independent of CD4.Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex.Memory CD8 T cells require CD8 coreceptor engagement for calcium mobilization and proliferation, but not cytokine production.Antagonism of cytotoxic T-lymphocyte activation by soluble CD8.Improved detection of melanoma antigen-specific T cells expressing low or high levels of CD8 by HLA-A2 tetramers presenting a Melan-A/Mart-1 peptide analogueCD8αβ Has Two Distinct Binding Modes of Interaction with Peptide-Major Histocompatibility Complex Class IDirect recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction
P2860
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P2860
Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 1990
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Recognition by CD8 on cytotoxi ...... ize the same class I molecule.
@en
Recognition by CD8 on cytotoxi ...... ize the same class I molecule.
@nl
type
label
Recognition by CD8 on cytotoxi ...... ize the same class I molecule.
@en
Recognition by CD8 on cytotoxi ...... ize the same class I molecule.
@nl
prefLabel
Recognition by CD8 on cytotoxi ...... ize the same class I molecule.
@en
Recognition by CD8 on cytotoxi ...... ize the same class I molecule.
@nl
P2093
P2860
P356
P1476
Recognition by CD8 on cytotoxi ...... ize the same class I molecule.
@en
P2093
A L Ingold
J M Connolly
T A Potter
T H Hansen
P2860
P304
P356
10.1073/PNAS.87.6.2137
P407
P577
1990-03-01T00:00:00Z