Minor antigen distribution predicts site-specific graft-versus-tumor activity of adoptively transferred, minor antigen-specific CD8 T Cells.
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Challenges and opportunities of allogeneic donor-derived CAR T cellsMurine allogeneic CD19 CAR T cells harbor potent antileukemic activity but have the potential to mediate lethal GVHD.CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity.Defining novel parameters for the optimal priming and expansion of minor histocompatibility antigen-specific T cells in culture.Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen.TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance.
P2860
Minor antigen distribution predicts site-specific graft-versus-tumor activity of adoptively transferred, minor antigen-specific CD8 T Cells.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 17 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Minor antigen distribution pre ...... antigen-specific CD8 T Cells.
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Minor antigen distribution pre ...... antigen-specific CD8 T Cells.
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type
label
Minor antigen distribution pre ...... antigen-specific CD8 T Cells.
@en
Minor antigen distribution pre ...... antigen-specific CD8 T Cells.
@nl
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Minor antigen distribution pre ...... antigen-specific CD8 T Cells.
@en
Minor antigen distribution pre ...... antigen-specific CD8 T Cells.
@nl
P2093
P2860
P1476
Minor antigen distribution pre ...... antigen-specific CD8 T Cells.
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P2093
Haiying Qin
Jessica C Shand
Nicole Nasholm
Terry J Fry
P2860
P356
10.1016/J.BBMT.2013.10.009
P577
2013-10-17T00:00:00Z