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THE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASECrystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesteraseTacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivoNew acetylcholinesterase inhibitors for Alzheimer's diseaseStructure-based search for new inhibitors of cholinesterases.Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease.Pyranopyrazolotacrines as nonneurotoxic, Aβ-anti-aggregating and neuroprotective agents for Alzheimer's disease.Synergistic inhibition of butyrylcholinesterase by galantamine and citalopram.The discovery of new acetylcholinesterase inhibitors derived from pharmacophore modeling, virtual screening, docking simulation and bioassays.2,3-dihydro-1H-cyclopenta[b]quinoline derivatives as acetylcholinesterase inhibitors-synthesis, radiolabeling and biodistribution.Synthesis and biological assessment of racemic benzochromenopyrimidinetriones as promising agents for Alzheimer's disease therapy.Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer's disease.Acetylcholinesterase inhibitors: a patent review (2008 - present).Bismuth compounds in medicinal chemistry.Multi-target design strategies in the context of Alzheimer's disease: acetylcholinesterase inhibition and NMDA receptor antagonism as the driving forces.Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration.Emerging Targets in Photopharmacology.Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological TreatmentNovel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer's disease.Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer.Acetylcholinesterase inhibitors with photoswitchable inhibition of β-amyloid aggregation.Coumarin derivatives bearing benzoheterocycle moiety: synthesis, cholinesterase inhibitory, and docking simulation study.Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer's disease.Molecular perception of interactions between bis(7)tacrine and cystamine-tacrine dimer with cholinesterases as the promising proposed agents for the treatment of Alzheimer's disease.DFT and TDDFT investigation of the Schiff base formed by tacrine and saccharin.Synthesis of 9-Aminoacridine Derivatives as Anti-Alzheimer Agents.Design, synthesis and evaluation of novel tacrine-rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease.5-Methyl--(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5-indolo[2,3-]quinolin-11-amine: a highly potent human cholinesterase inhibitorIdentification of novel acetylcholinesterase inhibitors designed by pharmacophore-based virtual screening, molecular docking and bioassay
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Tacrine derivatives and Alzheimer's disease.
@en
Tacrine derivatives and Alzheimer's disease.
@nl
type
label
Tacrine derivatives and Alzheimer's disease.
@en
Tacrine derivatives and Alzheimer's disease.
@nl
prefLabel
Tacrine derivatives and Alzheimer's disease.
@en
Tacrine derivatives and Alzheimer's disease.
@nl
P2093
P1476
Tacrine derivatives and Alzheimer's disease
@en
P2093
C Melchiorre
M L Bolognesi
V Tumiatti
P304
P356
10.2174/092986710791111206
P577
2010-01-01T00:00:00Z