Partners in crime: bidirectional transcription in unstable microsatellite disease.
about
A natural antisense transcript at the Huntington's disease repeat locus regulates HTT expressionNew insights into repeat instability: role of RNA•DNA hybridsRAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disordersInvolvement of long noncoding RNAs in diseases affecting the central nervous systemTriplet repeat-derived siRNAs enhance RNA-mediated toxicity in a Drosophila model for myotonic dystrophy5meCpG epigenetic marks neighboring a primate-conserved core promoter short tandem repeat indicate X-chromosome inactivationDeveloping informative microsatellite makers for non-model species using reference mapping against a model species' genomeProcessing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability.CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA.Repeat associated non-ATG translation initiation: one DNA, two transcripts, seven reading frames, potentially nine toxic entities!RNA-protein interactions in unstable microsatellite diseases.Ubiquitous expression of CUG or CAG trinucleotide repeat RNA causes common morphological defects in a Drosophila model of RNA-mediated pathologyNon-ATG-initiated translation directed by microsatellite expansions.Repeat associated non-ATG (RAN) translation: new starts in microsatellite expansion disorders.Trinucleotide expansion in disease: why is there a length threshold?Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeatsTriplet repeat RNA structure and its role as pathogenic agent and therapeutic targetRNA-binding protein misregulation in microsatellite expansion disordersChromatin changes in the development and pathology of the Fragile X-associated disorders and Friedreich ataxia.The disease-associated r(GGGGCC)n repeat from the C9orf72 gene forms tract length-dependent uni- and multimolecular RNA G-quadruplex structuresThe Enemy within: Innate Surveillance-Mediated Cell Death, the Common Mechanism of Neurodegenerative Disease.Bidirectional transcription of trinucleotide repeats: roles for excision repair.Evidence relevant to untargeted and transgenerational effects in the offspring of irradiated parentsRNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases.Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcriptsRepeat-associated non-ATG (RAN) translation in neurological disease.Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration.Consensus paper: pathological mechanisms underlying neurodegeneration in spinocerebellar ataxias.Most expression and splicing changes in myotonic dystrophy type 1 and type 2 skeletal muscle are shared with other muscular dystrophies.Mechanisms of toxicity in C9FTLD/ALS.Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions.Cellular toxicity of expanded RNA repeats: focus on RNA foci.RNA-binding proteins in microsatellite expansion disorders: mediators of RNA toxicity.Small non-coding RNAs add complexity to the RNA pathogenic mechanisms in trinucleotide repeat expansion diseases.Brain pathology in myotonic dystrophy: when tauopathy meets spliceopathy and RNAopathy.Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble.Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9.RNA toxicity induced by expanded CAG repeats in Huntington's disease.R Loops and Links to Human Disease.The role of RNA metabolism in neurological diseases.
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Partners in crime: bidirectional transcription in unstable microsatellite disease.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 04 April 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Partners in crime: bidirectional transcription in unstable microsatellite disease.
@en
Partners in crime: bidirectional transcription in unstable microsatellite disease.
@nl
type
label
Partners in crime: bidirectional transcription in unstable microsatellite disease.
@en
Partners in crime: bidirectional transcription in unstable microsatellite disease.
@nl
prefLabel
Partners in crime: bidirectional transcription in unstable microsatellite disease.
@en
Partners in crime: bidirectional transcription in unstable microsatellite disease.
@nl
P2093
P2860
P356
P1476
Partners in crime: bidirectional transcription in unstable microsatellite disease.
@en
P2093
Konstantinos Charizanis
Maurice S Swanson
Ranjan Batra
P2860
P304
P356
10.1093/HMG/DDQ132
P577
2010-04-04T00:00:00Z