Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble.
about
Structural studies of CNG repeatsTwisting right to left: A…A mismatch in a CAG trinucleotide repeat overexpansion provokes left-handed Z-DNA conformationDNA secondary structure at chromosomal fragile sites in human disease.Strong transcription blockage mediated by R-loop formation within a G-rich homopurine-homopyrimidine sequence localized in the vicinity of the promoter.RNA-protein interactions in unstable microsatellite diseases.Nucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instabilityDirect and inverted repeats elicit genetic instability by both exploiting and eluding DNA double-strand break repair systems in mycobacteria.DNA topoisomerases participate in fragility of the oncogene RET.PNA binding to the non-template DNA strand interferes with transcription, suggesting a blockage mechanism mediated by R-loop formation.FRA2A is a CGG repeat expansion associated with silencing of AFF3A genome-wide map of adeno-associated virus-mediated human gene targetingInstability of (CTG)n•(CAG)n trinucleotide repeats and DNA synthesisSearching for non-B DNA-forming motifs using nBMST (non-B DNA motif search tool)Transcription as a source of genome instability.Oligodeoxynucleotide binding to (CTG) · (CAG) microsatellite repeats inhibits replication fork stalling, hairpin formation, and genome instability.Role of DNA secondary structures in fragile site breakage along human chromosome 10Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequencesExpanded complexity of unstable repeat diseases.Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR.Convergent transcription through microsatellite repeat tracts induces cell death.Fanconi anemia pathway regulates convergent transcription-induced cell death at trinucleotide repeats in human cells.Coupling transcriptional state to large-scale repeat expansions in yeast.E-motif formed by extrahelical cytosine bases in DNA homoduplexes of trinucleotide and hexanucleotide repeats.A novel mode for transcription inhibition mediated by PNA-induced R-loops with a model in vitro system.
P2860
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P2860
Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble.
@en
type
label
Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble.
@en
prefLabel
Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble.
@en
P2860
P356
P1433
P1476
Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble.
@en
P2093
John H Wilson
P2860
P304
P356
10.4161/CC.10.4.14729
P577
2011-02-15T00:00:00Z