Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area.
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Ventral Tegmental Area Afferents and Drug-Dependent BehaviorsSex Differences in Kappa Opioid Receptor Function and Their Potential Impact on AddictionDrug withdrawal conceptualized as a stressor.The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems.VTA dopamine neuron plasticity - the unusual suspects.Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress.The kappa opioid receptor: from addiction to depression, and back.To ingest or rest? Specialized roles of lateral hypothalamic area neurons in coordinating energy balance.Hypocretin/Orexin regulation of dopamine signaling and cocaine self-administration is mediated predominantly by hypocretin receptor 1.Motivational activation: a unifying hypothesis of orexin/hypocretin functionBinge-like consumption of ethanol and other salient reinforcers is blocked by orexin-1 receptor inhibition and leads to a reduction of hypothalamic orexin immunoreactivity.Optogenetic evidence for inhibitory signaling from orexin to MCH neurons via local microcircuitsKappa opioid receptor signaling in the brain: Circuitry and implications for treatment.Hypothalamic neuropeptide signaling in alcohol addictionAcetylcholine Acts through Nicotinic Receptors to Enhance the Firing Rate of a Subset of Hypocretin Neurons in the Mouse Hypothalamus through Distinct Presynaptic and Postsynaptic Mechanisms(.)The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking.Progressive Loss of the Orexin Neurons Reveals Dual Effects on WakefulnessNigrostriatal Dopamine Acting on Globus Pallidus Regulates Sleep.mTOR signalling in the nucleus accumbens shell is critical for augmented effect of TFF3 on behavioural response to cocaine.The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation.Opposing roles of cotransmission of dynorphin and hypocretin on reward and motivation.The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism.Interactions of the histamine and hypocretin systems in CNS disorders.Hypocretins, Neural Systems, Physiology, and Psychiatric Disorders.Computational implications of biophysical diversity and multiple timescales in neurons and synapses for circuit performance.Suvorexant, an orexin/hypocretin receptor antagonist, attenuates motivational and hedonic properties of cocaine.Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner.Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour.Neuroendocrine Regulation of Anxiety: Beyond the Hypothalamic-Pituitary-Adrenal Axis.How contexts promote and prevent relapse to drug seeking.Orexin signaling in rostral lateral hypothalamus and nucleus accumbens shell in the control of spontaneous physical activity in high- and low-activity rats.Hypocretin/Orexin and Plastic Adaptations Associated with Drug Abuse.Functional consequences of neuropeptide and small-molecule co-transmission.Upregulation of orexin/hypocretin expression in aged rats: Effects on feeding latency and neurotransmission in the insular cortex.Individual differences in orexin-I receptor modulation of motivation for the opioid remifentanil.Neurochemical Heterogeneity Among Lateral Hypothalamic Hypocretin/Orexin and Melanin-Concentrating Hormone Neurons Identified Through Single-Cell Gene Expression AnalysisWhat optogenetic stimulation is telling us (and failing to tell us) about fast neurotransmitters and neuromodulators in brain circuits for wake-sleep regulationHypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine.Dynorphin inhibits basal forebrain cholinergic neurons by pre- and postsynaptic mechanisms.Opioid and hypocretin neuromodulation of ventral tegmental area neuronal subpopulations.
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P2860
Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 March 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Hypocretin (orexin) facilitate ...... hin in ventral tegmental area.
@en
type
label
Hypocretin (orexin) facilitate ...... hin in ventral tegmental area.
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prefLabel
Hypocretin (orexin) facilitate ...... hin in ventral tegmental area.
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P2093
P2860
P356
P1476
Hypocretin (orexin) facilitate ...... phin in ventral tegmental area
@en
P2093
George Voren
Jennifer L Thompson
John W Muschamp
Jonathan A Hollander
Linda C Hassinger
Paul J Kenny
Sara Onvani
Theodore M Kamenecka
William A Carlezon
P2860
P304
P356
10.1073/PNAS.1315542111
P407
P577
2014-03-24T00:00:00Z