Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR
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Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptorSB-334867-A: the first selective orexin-1 receptor antagonistPhysiology of the orexinergic/hypocretinergic system: a revisit in 2012The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptorOX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanismsCharacterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptorsOrexin A and B evoke noradrenaline release from rat cerebrocortical slicesGastrointestinal-projecting neurones in the dorsal motor nucleus of the vagus exhibit direct and viscerotopically organized sensitivity to orexinThe neuropharmacology of relapse to food seeking: methodology, main findings, and comparison with relapse to drug seeking.Orexin signaling in recombinant neuron-like cells.Short food deprivation inhibits orexin receptor 1 expression and orexin-A induced intracellular calcium signaling in acutely isolated duodenal enterocytes.The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats.SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats.Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination.The hypocretins: setting the arousal threshold.Functions of the orexinergic/hypocretinergic system.Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCĪ± and ERK1/2 signalsA comparative analysis of the distribution of immunoreactive orexin A and B in the brains of nocturnal and diurnal rodents.Neuropeptides controlling energy balance: orexins and neuromedins.Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in ratsThe use of the reinstatement model to study relapse to palatable food seeking during dieting.Reinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: independence from the local corticotropin-releasing factor networkDifferential actions of orexin receptors in brainstem cholinergic and monoaminergic neurons revealed by receptor knockouts: implications for orexinergic signaling in arousal and narcolepsy.Orexin/hypocretin receptor signalling: a functional perspective.Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area.Central functions of the orexinergic system.Orexin/hypocretin receptor signalling cascades.Orexin/hypocretin based pharmacotherapies for the treatment of addiction: DORA or SORA?The hypocretin/orexin system: an increasingly important role in neuropsychiatry.Role of Orexin-A in Hypertension and Obesity.OX2R activation induces PKC-mediated ERK and CREB phosphorylation.Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.Hypocretin (orexin) regulates glutamate input to fast-spiking interneurons in layer V of the Fr2 region of the murine prefrontal cortexThe sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation.Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration.Comparison of functional profiles at human recombinant somatostatin sst2 receptor: simultaneous determination of intracellular Ca2+ and luciferase expression in CHO-K1 cellsThe hypocretins are weak agonists at recombinant human orexin-1 and orexin-2 receptorsExpression of orexin A and its receptor 1 in the human prostate.Calcium affects OX1 orexin (hypocretin) receptor responses by modifying both orexin binding and the signal transduction machinery.Evaluation of FLIPR Calcium 3 Assay Kit--a new no-wash fluorescence calcium indicator reagent.
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P2860
Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR
description
1999 nĆ® lÅ«n-bĆ»n
@nan
1999 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« ÕÕ„ÕŗÕæÕ„Õ“Õ¢Õ„ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕøÖÕ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ ÕµÖ
Õ¤ÕøÖÕ”Õ®
@hyw
1999 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« Õ½Õ„ÕŗÕæÕ„Õ“Õ¢Õ„ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
1999幓ć®č«ę
@ja
1999幓č«ę
@yue
1999幓č«ę
@zh-hant
1999幓č«ę
@zh-hk
1999幓č«ę
@zh-mo
1999幓č«ę
@zh-tw
1999幓č®ŗę
@wuu
name
Characterization of recombinan ...... er ovary cell-line using FLIPR
@ast
Characterization of recombinan ...... er ovary cell-line using FLIPR
@en
Characterization of recombinan ...... er ovary cell-line using FLIPR
@nl
type
label
Characterization of recombinan ...... er ovary cell-line using FLIPR
@ast
Characterization of recombinan ...... er ovary cell-line using FLIPR
@en
Characterization of recombinan ...... er ovary cell-line using FLIPR
@nl
prefLabel
Characterization of recombinan ...... er ovary cell-line using FLIPR
@ast
Characterization of recombinan ...... er ovary cell-line using FLIPR
@en
Characterization of recombinan ...... er ovary cell-line using FLIPR
@nl
P2093
P2860
P356
P1476
Characterization of recombinan ...... er ovary cell-line using FLIPR
@en
P2093
D N Middlemiss
J C Jerman
N A Elshourbagy
P R Murdock
S J Brough
S L Rushton
P2860
P356
10.1038/SJ.BJP.0702780
P407
P577
1999-09-01T00:00:00Z