Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation.
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The contribution of mouse models to the understanding of constitutional thrombocytopeniaUnderstanding platelet generation from megakaryocytes: implications for in vitro-derived plateletsLinkage between the mechanisms of thrombocytopenia and thrombopoiesisGenomic landscape of megakaryopoiesis and platelet function defectsIL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs.Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture.Genetic studies reveal an unexpected negative regulatory role for Jak2 in thrombopoiesis.Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice.The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.BCL-2 is dispensable for thrombopoiesis and platelet survivalNovel mechanisms of platelet clearance and thrombopoietin regulation.Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling.The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin.The role of bone marrow microenvironment in platelet production and their implications for the treatment of thrombocytopenic diseases.Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance.The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasmThrombopoietin treatment of one graft in a double cord blood transplant provides early platelet recovery while contributing to long-term engraftment in NSG mice.Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model.Characterisation of the Whole Blood mRNA Transcriptome in Holstein-Friesian and Jersey Calves in Response to Gradual Weaning.Regulating billions of blood platelets: glycans and beyond.A thrombopoietin receptor antagonist is capable of depleting myelofibrosis hematopoietic stem and progenitor cells.JAK2V617F-mutant megakaryocytes contribute to hematopoietic stem/progenitor cell expansion in a model of murine myeloproliferation.Megakaryocyte rupture for acute platelet needs.Overview of Transgenic Mouse Models of Myeloproliferative Neoplasms (MPNs).Genetic Alterations of the Thrombopoietin/MPL/JAK2 Axis Impacting Megakaryopoiesis.Effect of thrombopoietin receptor agonists on leukocyte and haematopoietic stem and progenitor cells in the peripheral blood of patients with immune thrombocytopenic purpura.Tribute to Donald Metcalf.Human adipose tissue-derived stromal cells can differentiate into megakaryocytes and platelets by secreting endogenous thrombopoietin.Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling.Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice.Cells with hematopoietic potential reside within mouse proepicardium.D-dencichine Regulates Thrombopoiesis by Promoting Megakaryocyte Adhesion, Migration and Proplatelet Formation.Megakaryocyte and Osteoblast Interactions Modulate Bone Mass and Hematopoiesis.Ruxolitinib- but not fedratinib-induced extreme thrombocytosis: the combination therapy with hydroxyurea and ruxolitinib is effective in reducing platelet count and splenomegaly/constitutional symptomsExpression of CD markers in JAK2 positive myeloproliferative neoplasms: Prognostic significance
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Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 07 April 2014
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mpl expression on megakaryocyt ...... to prevent myeloproliferation.
@en
Mpl expression on megakaryocyt ...... to prevent myeloproliferation.
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type
label
Mpl expression on megakaryocyt ...... to prevent myeloproliferation.
@en
Mpl expression on megakaryocyt ...... to prevent myeloproliferation.
@nl
prefLabel
Mpl expression on megakaryocyt ...... to prevent myeloproliferation.
@en
Mpl expression on megakaryocyt ...... to prevent myeloproliferation.
@nl
P2093
P2860
P50
P356
P1476
Mpl expression on megakaryocyt ...... to prevent myeloproliferation.
@en
P2093
Craig D Hyland
Jian-Guo Zhang
Marion Lebois
Tracey M Baldwin
Warren S Alexander
P2860
P304
P356
10.1073/PNAS.1404354111
P407
P577
2014-04-07T00:00:00Z