Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models.
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Continuous quinacrine treatment results in the formation of drug-resistant prionsHeparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seedsSafety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trialPrion diseases: immunotargets and therapyPrion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic targetEffective gene therapy in a mouse model of prion diseasesCalcineurin inhibition at the clinical phase of prion disease reduces neurodegeneration, improves behavioral alterations and increases animal survivalStructure of the Flexible Amino-Terminal Domain of Prion Protein Bound to a Sulfated GlycanPharmacokinetics of quinacrine efflux from mouse brain via the P-glycoprotein efflux transporterStructure-Based Drug Discovery for Prion Disease Using a Novel Binding SimulationThe efficacy of tetracyclines in peripheral and intracerebral prion infection.Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoringEfficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity.Glycosaminoglycan sulphation affects the seeded misfolding of a mutant prion proteinPostmortem findings in a case of variant Creutzfeldt-Jakob disease treated with intraventricular pentosan polysulfate.Diphenylpyrazole-derived compounds increase survival time of mice after prion infection.Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cellsMefloquine, an antimalaria drug with antiprion activity in vitro, lacks activity in vivoCharacterizing antiprion compounds based on their binding properties to prion proteins: implications as medical chaperones.A porphyrin increases survival time of mice after intracerebral prion infectionVariant CJD. 18 years of research and surveillance.Structure-based drug design identifies polythiophenes as antiprion compounds.Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides.An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity.Enhanced antiscrapie effect using combination drug treatmentIdentification of chemoattractive factors involved in the migration of bone marrow-derived mesenchymal stem cells to brain lesions caused by prionsMolecular neurology of prion disease.Rapidly progressive dementias and the treatment of human prion diseases.Phosphorothioate oligonucleotides reduce PrP levels and prion infectivity in cultured cells.Recent advances in prion chemotherapeutics.Rational targeting for prion therapeutics.An overview of transmissible spongiform encephalopathies.The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc).A Single Subcutaneous Injection of Cellulose Ethers Administered Long before Infection Confers Sustained Protection against Prion Diseases in RodentsAntiprion activity of cholesterol esterification modulators: a comparative study using ex vivo sheep fibroblasts and lymphocytes and mouse neuroblastoma cell lines.Therapeutic approaches for prion disorders.Intrathecal pumps.Effect of transplantation of bone marrow-derived mesenchymal stem cells on mice infected with prions.Therapies for human prion diseasesEthics in prion disease.
P2860
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P2860
Treatment of transmissible spongiform encephalopathy by intraventricular drug infusion in animal models.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2004
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Treatment of transmissible spo ...... rug infusion in animal models.
@en
Treatment of transmissible spo ...... rug infusion in animal models.
@nl
type
label
Treatment of transmissible spo ...... rug infusion in animal models.
@en
Treatment of transmissible spo ...... rug infusion in animal models.
@nl
prefLabel
Treatment of transmissible spo ...... rug infusion in animal models.
@en
Treatment of transmissible spo ...... rug infusion in animal models.
@nl
P2093
P2860
P1433
P1476
Treatment of transmissible spo ...... rug infusion in animal models.
@en
P2093
Ikuko Murakami-Kubo
Katsumi Doh-ura
Kensuke Ishikawa
Kensuke Sasaki
Richard Race
Shirou Mohri
Toru Iwaki
P2860
P304
P356
10.1128/JVI.78.10.4999-5006.2004
P407
P577
2004-05-01T00:00:00Z