The herpes simplex virus type 1 UL20 protein modulates membrane fusion events during cytoplasmic virion morphogenesis and virus-induced cell fusion.
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Tegument Assembly and Secondary Envelopment of AlphaherpesvirusesHerpes simplex virus 1 protein UL37 interacts with viral glycoprotein gK and membrane protein UL20 and functions in cytoplasmic virion envelopment.The herpes simplex virus type 1 UL20 protein and the amino terminus of glycoprotein K (gK) physically interact with gB.The amino terminus of herpes simplex virus 1 glycoprotein K is required for virion entry via the paired immunoglobulin-like type-2 receptor alphaBeta interferon and gamma interferon synergize to block viral DNA and virion synthesis in herpes simplex virus-infected cells.Mutations within the pathogenic region of herpes simplex virus 1 gK signal sequences alter cell surface expression and neurovirulenceGenetic analysis of the herpes simplex virus type 1 UL20 protein domains involved in cytoplasmic virion envelopment and virus-induced cell fusion.Site-specific proteolytic cleavage of the amino terminus of herpes simplex virus glycoprotein K on virion particles inhibits virus entry.Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane.Epitope mapping of HSV-1 glycoprotein K (gK) reveals a T cell epitope located within the signal domain of gKThe herpes simplex virus UL20 protein functions in glycoprotein K (gK) intracellular transport and virus-induced cell fusion are independent of UL20 functions in cytoplasmic virion envelopmentFunctional and physical interactions of the herpes simplex virus type 1 UL20 membrane protein with glycoprotein KReduction in severity of a herpes simplex virus type 1 murine infection by treatment with a ribozyme targeting the UL20 gene RNA.Single dose of glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responsesContributions of herpes simplex virus 1 envelope proteins to entry by endocytosis.The amino terminus of herpes simplex virus type 1 glycoprotein K (gK) modulates gB-mediated virus-induced cell fusion and virion egress.Elucidation of the block to herpes simplex virus egress in the absence of tegument protein UL16 reveals a novel interaction with VP22.Herpes simplex virus type 1 glycoprotein K and the UL20 protein are interdependent for intracellular trafficking and trans-Golgi network localizationHerpes simplex virus type 1 gK is required for gB-mediated virus-induced cell fusion, while neither gB and gK nor gB and UL20p function redundantly in virion de-envelopmentHerpesviruses remodel host membranes for virus egress.Reconstitution of herpes simplex virus type 1 nuclear capsid egress in vitro.Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at the trans-Golgi Network To Promote Virus Replication.Glycoproteins gB and gH are required for syncytium formation but not for herpesvirus-induced nuclear envelope breakdown.Functional hierarchy of herpes simplex virus 1 viral glycoproteins in cytoplasmic virion envelopment and egressDeletion of a Predicted β-Sheet Domain within the Amino Terminus of Herpes Simplex Virus Glycoprotein K Conserved among Alphaherpesviruses Prevents Virus Entry into Neuronal Axons.Inner tegument protein pUL37 of herpes simplex virus type 1 is involved in directing capsids to the trans-Golgi network for envelopment.Comprehensive characterization of extracellular herpes simplex virus type 1 virions.The herpes simplex virus type 1 (HSV-1) glycoprotein K(gK) is essential for viral corneal spread and neuroinvasiveness.The UL21 Tegument Protein of Herpes Simplex Virus 1 Is Differentially Required for the Syncytial Phenotype.Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K.UL20 protein functions precede and are required for the UL11 functions of herpes simplex virus type 1 cytoplasmic virion envelopment.Herpes simplex virus Membrane Fusion.The equine herpesvirus 1 UL20 product interacts with glycoprotein K and promotes egress of mature particles.Herpes Simplex Virus 1 UL37 Protein Tyrosine Residues Conserved among All Alphaherpesviruses Are Required for Interactions with Glycoprotein K, Cytoplasmic Virion Envelopment, and Infectious Virus Production.Phenylalanine residues at the carboxyl terminus of the herpes simplex virus 1 UL20 membrane protein regulate cytoplasmic virion envelopment and infectious virus productionHSV-1 gM and the gK/pUL20 complex are important for the localization of gD and gH/L to viral assembly sites.A replication competent HSV-1(McKrae) with a mutation in the amino-terminus of glycoprotein K (gK) is unable to infect mouse trigeminal ganglia after cornea infection.The herpes simplex virus type 1 glycoprotein D (gD) cytoplasmic terminus and full-length gE are not essential and do not function in a redundant manner for cytoplasmic virion envelopment and egress.The absence of DHHC3 affects primary and latent HSV-1 infection.Inner tegument proteins of Herpes Simplex Virus are sufficient for intracellular capsid motility in neurons but not for axonal targeting.
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The herpes simplex virus type 1 UL20 protein modulates membrane fusion events during cytoplasmic virion morphogenesis and virus-induced cell fusion.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on May 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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The herpes simplex virus type ...... and virus-induced cell fusion.
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The herpes simplex virus type ...... and virus-induced cell fusion.
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The herpes simplex virus type ...... and virus-induced cell fusion.
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The herpes simplex virus type ...... and virus-induced cell fusion.
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The herpes simplex virus type ...... and virus-induced cell fusion.
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The herpes simplex virus type ...... and virus-induced cell fusion.
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The herpes simplex virus type ...... and virus-induced cell fusion.
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Jeffrey M Melancon
Joel D Baines
Konstantin G Kousoulas
Timothy P Foster
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10.1128/JVI.78.10.5347-5357.2004
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2004-05-01T00:00:00Z