The herpes simplex virus type 1 (HSV-1) glycoprotein K(gK) is essential for viral corneal spread and neuroinvasiveness.
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Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entryOncolytic virotherapy using herpes simplex virus: how far have we come?Genital Herpes: Insights into Sexually Transmitted Infectious DiseaseAmino acid differences in glycoproteins B (gB), C (gC), H (gH) and L (gL) are associated with enhanced herpes simplex virus type-1 (McKrae) entry via the paired immunoglobulin-like type-2 receptor α.The amino terminus of herpes simplex virus 1 glycoprotein K is required for virion entry via the paired immunoglobulin-like type-2 receptor alphaA single intramuscular vaccination of mice with the HSV-1 VC2 virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal challenge with virulent HSV-1 and HSV-2 strains.Mutations within the pathogenic region of herpes simplex virus 1 gK signal sequences alter cell surface expression and neurovirulenceEfficient generation and rapid isolation via stoplight recombination of Herpes simplex viruses expressing model antigenic and immunological epitopes.Changes in Corneal Innervation after HSV-1 Latency Established with Different Reactivation Phenotypes.A herpes simplex virus 1 (McKrae) mutant lacking the glycoprotein K gene is unable to infect via neuronal axons and egress from neuronal cell bodies.HSV-1 strain McKrae is more neuroinvasive than HSV-1 KOS after corneal or vaginal inoculation in miceHerpes Simplex Vaccines: Prospects of Live-attenuated HSV Vaccines to Combat Genital and Ocular infections.Single dose of glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responsesContributions of herpes simplex virus 1 envelope proteins to entry by endocytosis.Early events in herpes simplex virus lifecycle with implications for an infection of lifetimeCell entry mechanisms of HSV: what we have learned in recent years.Deletion of a Predicted β-Sheet Domain within the Amino Terminus of Herpes Simplex Virus Glycoprotein K Conserved among Alphaherpesviruses Prevents Virus Entry into Neuronal Axons.Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K.Binding of HSV-1 glycoprotein K (gK) to signal peptide peptidase (SPP) is required for virus infectivityFunctional hierarchy of herpes simplex virus type-1 membrane proteins in corneal infection and virus transmission to ganglionic neurons.A replication competent HSV-1(McKrae) with a mutation in the amino-terminus of glycoprotein K (gK) is unable to infect mouse trigeminal ganglia after cornea infection.Analysis of the Protective Immunity Induced by Herpes Simplex Virus 1 Strain M3 with an Attenuated Phenotype Due to Mutations in the Viral ul7, ul41, and LAT Genes.The absence of DHHC3 affects primary and latent HSV-1 infection.The Amino-terminus of HSV-1 Glycoprotein K (gK) is Required for gB Binding to Akt, Release of Intracellular Calcium and Fusion of the Viral Envelope with Plasma Membranes.The HSV-1 mechanisms of cell-to-cell spread and fusion are critically dependent on host PTP1B.
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P2860
The herpes simplex virus type 1 (HSV-1) glycoprotein K(gK) is essential for viral corneal spread and neuroinvasiveness.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
The herpes simplex virus type ...... spread and neuroinvasiveness.
@en
The herpes simplex virus type 1
@nl
type
label
The herpes simplex virus type ...... spread and neuroinvasiveness.
@en
The herpes simplex virus type 1
@nl
prefLabel
The herpes simplex virus type ...... spread and neuroinvasiveness.
@en
The herpes simplex virus type 1
@nl
P2093
P2860
P1433
P1476
The herpes simplex virus type ...... spread and neuroinvasiveness.
@en
P2093
Andrew T David
K G Kousoulas
T P Foster
V N Chouljenko
P2860
P304
P356
10.1080/02713680802130362
P577
2008-05-01T00:00:00Z