Alzheimer's disease: strategies for disease modification.
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Alzheimer mechanisms and therapeutic strategiesGrowth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor proteinInteractome mapping suggests new mechanistic details underlying Alzheimer's diseaseAn epigenetic blockade of cognitive functions in the neurodegenerating brainBiomaterials for the Treatment of Alzheimer's DiseaseIntracellular Calcium Dysregulation: Implications for Alzheimer's DiseaseRegeneration strategies after the adult mammalian central nervous system injury-biomaterialsModulation of neurotrophic signaling pathways by polyphenolsAlzheimer's therapeutics: translation of preclinical science to clinical drug developmentPathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body diseaseTargeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseasesApplications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseasesNeuroinflammation in Alzheimer's diseaseNeural stem cells could serve as a therapeutic material for age-related neurodegenerative diseasesDrug repositioning approaches for the discovery of new therapeutics for Alzheimer's diseaseMild cognitive impairment. Part 2: Biological markers for diagnosis and prediction of dementia in Alzheimer's diseasePreclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s DiseaseIntraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaquesAAV2/1 CD74 Gene Transfer Reduces β-amyloidosis and Improves Learning and Memory in a Mouse Model of Alzheimer's Disease.Structure-Based Design of Highly Selective β-Secretase Inhibitors: Synthesis, Biological Evaluation, and Protein–Ligand X-ray Crystal StructureDiscovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer DiseaseRisk factor SORL1: from genetic association to functional validation in Alzheimer's diseaseACAT1/SOAT1 as a therapeutic target for Alzheimer's diseaseAlzheimer's disease: Unique markers for diagnosis & new treatment modalitiesOlive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer's disease: in vitro and in vivo studiesA review of pterostilbene antioxidant activity and disease modificationCoffee and caffeine potentiate the antiamyloidogenic activity of melatonin via inhibition of Aβ oligomerization and modulation of the Tau-mediated pathway in N2a/APP cellsInteraction between amyloid beta peptide and an aggregation blocker peptide mimicking islet amyloid polypeptideBACE1 inhibition induces a specific cerebrospinal fluid β-amyloid pattern that identifies drug effects in the central nervous systemDOGS: reaction-driven de novo design of bioactive compoundsRapamycin attenuates the progression of tau pathology in P301S tau transgenic miceFLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylationGalantamine slows down plaque formation and behavioral decline in the 5XFAD mouse model of Alzheimer's disease.Magnesium protects cognitive functions and synaptic plasticity in streptozotocin-induced sporadic Alzheimer's modelβ-Amyloid1-42, HIV-1Ba-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide AHigh Resolution Discovery Proteomics Reveals Candidate Disease Progression Markers of Alzheimer's Disease in Human Cerebrospinal FluidEffect of LXR/RXR agonism on brain and CSF Aβ40 levels in ratsAmyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer diseaseMeta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease
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Alzheimer's disease: strategies for disease modification.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
gotara zanistî
@ku-latn
scientific article published on May 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
name
Alzheimer's disease: strategies for disease modification.
@en
Alzheimer's disease: strategies for disease modification.
@nl
type
label
Alzheimer's disease: strategies for disease modification.
@en
Alzheimer's disease: strategies for disease modification.
@nl
prefLabel
Alzheimer's disease: strategies for disease modification.
@en
Alzheimer's disease: strategies for disease modification.
@nl
P356
P1476
Alzheimer's disease: strategies for disease modification.
@en
P2093
Martin Citron
P2888
P304
P356
10.1038/NRD2896
P577
2010-05-01T00:00:00Z