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NOTCH1 PEST domain mutants bind DLL1NOTCH1 PEST domain mutants bind DLL4NOTCH1 PEST domain mutants bind JAG1NOTCH1 PEST domain mutants bind JAG2Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutantsADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutantsNEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutantsNICD1 PEST domain mutants translocate from cytosol to nucleusNICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL)NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAMLNOTCH1 PEST domain mutants bind HES1 promoterNOTCH1 PEST domain mutants stimulate HES1 transcriptionNOTCH1 PEST domain mutants bind HES5 promoterNOTCH1 PEST domain mutants stimulate HES5 transcriptionNOTCH1 PEST domain mutants bind promoters of HEY genesNOTCH1 PEST domain mutants stimulate HEY transcriptionNOTCH1 PEST domain mutants bind MYC promoterNOTCH1 PEST domain mutants stimulate MYC transcriptionNOTCH1 PEST domain mutants coactivator complex binds CDK8:CCNCCDK8 phosphorylates NICD1 PEST domain mutantsp-NICD1 PEST domain mutants do not bind FBXW7
P361
Q37753090-71753BA5-C520-4787-A1D7-F04CD5A93885Q37753095-262E8089-5610-4D5E-8FF4-828DBD9B4DC4Q37753098-B45211BD-5CB4-411B-9DF3-0A0F20797619Q37753103-D6466667-AE09-4E8D-ABFF-2DF005A1428EQ37753108-CABBD98F-23C9-42FC-BB20-D37A5735B5F4Q37753112-79CC2F5E-5272-4749-8C0E-24A3A1F4457BQ37753116-43FE23A1-8502-4F7E-8C08-7E22AFA0DD8DQ37753120-0D4E3EC9-6D52-45BC-AD90-3F49DEDD7430Q37753125-17D577A4-DA1F-4F96-9097-8102910C42E0Q37753130-C1FD68F6-45C9-44E9-8B5A-96851DF37409Q37753135-0DA5F84E-5D1E-47FC-BA7A-CE28261CA783Q37753138-27543A41-7BDD-414F-A984-B080EC4E8FA1Q37753142-D6AC3C81-55E2-4511-B4D9-A7A0D7B6943AQ37753147-20644C5C-DDCC-4C15-8BD4-93BF81EC0C50Q37753152-5A3CD938-23D3-464E-9BA1-256EDF611506Q37753157-DB771950-F782-4C95-A5FD-2D809747DC99Q37753159-F69E5718-0C93-40E8-B9FC-07CB1B34AF36Q37753163-FD051EDF-F0C7-46F2-A910-DD2262FE81A6Q37753168-FDBF3D95-A19F-45B3-B56B-6B8D5D85FD81Q37753173-29083F39-2A5D-4073-93B8-2CEAB3B5631DQ37753177-0ADD889D-3376-4F00-BD54-A329F5A37A8A
P361
description
An instance of the biological ...... Domain Mutants in Homo sapiens
@en
name
Constitutive Signaling by NOTCH1 PEST Domain Mutants
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type
label
Constitutive Signaling by NOTCH1 PEST Domain Mutants
@en
prefLabel
Constitutive Signaling by NOTCH1 PEST Domain Mutants
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P2860
P527
P2860
P3937
R-HSA-2644606