FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors - Wikidata - awgldk - TriplyDB

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

http://www.wikidata.org/entity/Q36229551

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The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7 Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223 Direct inhibition of the NOTCH transcription factor complex Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?Notch signaling: its roles and therapeutic potential in hematological malignancies Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?Notch signaling deregulation in multiple myeloma: A rational molecular target RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine From fly wings to targeted cancer therapies: a centennial for notch signaling Notch signaling as a novel regulator of metabolism Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation.A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer.Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights The role of aberrant proteolysis in lymphomagenesis Prognostification of ALL by Cytogenetics Use of single nucleotide polymorphism array technology to improve the identification of chromosomal lesions in leukemia The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors The canonical Notch signaling pathway: unfolding the activation mechanism.Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis.Notch inhibitors as a new tool in the war on cancer: a pathway to watch.Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).Turn It Down a Notch Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia Global genomic characterization of acute lymphoblastic leukemia Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specification Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset Mammary development and breast cancer: the role of stem cells

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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

http://www.wikidata.org/entity/Q36229551

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

FBW7 mutations in leukemic cel ...... to gamma-secretase inhibitors

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FBW7 mutations in leukemic cel ...... to gamma-secretase inhibitors

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type

label

FBW7 mutations in leukemic cel ...... to gamma-secretase inhibitors

@ast

FBW7 mutations in leukemic cel ...... to gamma-secretase inhibitors

@en

prefLabel

FBW7 mutations in leukemic cel ...... to gamma-secretase inhibitors

@ast

FBW7 mutations in leukemic cel ...... to gamma-secretase inhibitors

@en

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Journal of Experimental Medicine

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FBW7 mutations in leukemic cel ...... to gamma-secretase inhibitors

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A Thomas Look

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Bruce E Clurman

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Christopher Winter

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Giulio Draetta

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James Hardwick

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Jennifer O'Neil

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Jonathan Grim

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Rob Pieters

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Rosalie Sears

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Sudhir Rao

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P2860

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases

Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination

Notch signaling: cell fate control and signal integration in development

Involvement of Notch1 in the development of mouse mammary tumors

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1813-1824

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10.1084/JEM.20070876

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8

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204

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Jules P Meijerink

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Deanne C Tibbitts

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2007-07-23T00:00:00Z

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6193053

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17646409

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2118656

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