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A Review of the Giant Protein Titin in Clinical Molecular Diagnostics of CardiomyopathiesBreakthrough in heart failure with preserved ejection fraction: are we there yet?Myocardial hypertrophy and its role in heart failure with preserved ejection fractionCardiac endothelium-myocyte interaction: clinical opportunities for new heart failure therapies regardless of ejection fractionWhat global diastolic function is, what it is not, and how to measure itThe cardiomyocyte protein αT-catenin contributes to asthma through regulating pulmonary vein inflammationMaturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissuesSingle molecule force spectroscopy on titin implicates immunoglobulin domain stability as a cardiac disease mechanism.Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.Mechano-signaling in heart failureHeart failure with preserved ejection fraction: molecular pathways of the aging myocardiumPhosphorylation of tropomodulin1 contributes to the regulation of actin filament architecture in cardiac muscle.DISC1 conditioned GWAS for psychosis proneness in a large Finnish birth cohort.Probing muscle ankyrin-repeat protein (MARP) structure and functionMouse intact cardiac myocyte mechanics: cross-bridge and titin-based stress in unactivated cells.Upstream open reading frame in 5'-untranslated region reduces titin mRNA translational efficiency.Contribution of titin and extracellular matrix to passive pressure and measurement of sarcomere length in the mouse left ventricle.Thick-filament strain and interfilament spacing in passive muscle: effect of titin-based passive tensionCardiac titin and heart disease.Increased myocardial stiffness due to cardiac titin isoform switching in a mouse model of volume overload limits eccentric remodelingGenetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes.Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle.Hyperphosphorylation of mouse cardiac titin contributes to transverse aortic constriction-induced diastolic dysfunctionHeart Failure with Preserved Ejection Fraction: Persistent Diagnosis, Therapeutic Enigma.A novel strategy for utilizing voice coil servoactuators in tensile tests of low volume protein hydrogels.Titin-actin interaction: PEVK-actin-based viscosity in a large animalProspects for In Vitro Myofilament Maturation in Stem Cell-Derived Cardiac Myocytes.A mouse model of heart failure with preserved ejection fraction due to chronic infusion of a low subpressor dose of angiotensin II.Stretch of contracting cardiac muscle abruptly decreases the rate of phosphate release at high and low calcium.Clinical evaluation of a matrix metalloproteinase-12 cleaved fragment of titin as a cardiovascular serological biomarker.Atomic model of the human cardiac muscle myosin filament.Phosphorylation modulates the mechanical stability of the cardiac myosin-binding protein C motif.Cell-free protein synthesis: the state of the art.Titin is a major human disease gene.Genetic complexity in hypertrophic cardiomyopathy revealed by high-throughput sequencing.Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.Right Ventricular Myocardial Stiffness in Experimental Pulmonary Arterial Hypertension: Relative Contribution of Fibrosis and Myofibril Stiffness.Titin-based stiffening of muscle fibers in Ehlers-Danlos SyndromeIntegrating the myocardial matrix into heart failure recognition and management.Obesity alters molecular and functional cardiac responses to ischemia/reperfusion and glucagon-like peptide-1 receptor agonism.
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
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name
Cardiac titin: a multifunctional giant
@en
Cardiac titin: a multifunctional giant.
@nl
type
label
Cardiac titin: a multifunctional giant
@en
Cardiac titin: a multifunctional giant.
@nl
prefLabel
Cardiac titin: a multifunctional giant
@en
Cardiac titin: a multifunctional giant.
@nl
P2860
P1433
P1476
Cardiac titin: a multifunctional giant
@en
P2093
Henk Granzier
Martin M LeWinter
P2860
P304
P356
10.1161/CIRCULATIONAHA.109.860171
P407
P577
2010-05-01T00:00:00Z