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A Review of the Giant Protein Titin in Clinical Molecular Diagnostics of CardiomyopathiesThe other side of the coin: the tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND-CDK4/6-RB axisGenetics and disease of ventricular muscle.Titin and desmosomal genes in the natural history of arrhythmogenic right ventricular cardiomyopathyMechanical dynamics in live cells and fluorescence-based force/tension sensorsNovex-3, the tiny titin of muscle.Genetic epidemiology of titin-truncating variants in the etiology of dilated cardiomyopathy.Influence of V54M mutation in giant muscle protein titin: a computational screening and molecular dynamics approach.Titin-mediated control of cardiac myofibrillar function.Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.Discovery of novel heart rate-associated loci using the Exome Chip.Rbm20-deficient cardiogenesis reveals early disruption of RNA processing and sarcomere remodeling establishing a developmental etiology for dilated cardiomyopathy.Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function.Arrhythmogenic right ventricular cardiomyopathy: From genetics to diagnostic and therapeutic challenges.Myocardial stiffness in patients with heart failure and a preserved ejection fraction: contributions of collagen and titinMyosin light chain phosphorylation to the rescue.Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and diseaseAttenuated sarcomere lengthening of the aged murine left ventricle observed using two-photon fluorescence microscopyGenetic Variation in Cardiomyopathy and Cardiovascular Disorders.Phosphorylating Titin's Cardiac N2B Element by ERK2 or CaMKIIδ Lowers the Single Molecule and Cardiac Muscle ForceAn internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafishRole of Titin Missense Variants in Dilated Cardiomyopathy.A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy.Increasing Role of Titin Mutations in Neuromuscular Disorders.Functional roles of alternative splicing factors in human disease.The (dys)functional extracellular matrix.Exon- and contraction-dependent functions of titin in sarcomere assembly.Overview of the Muscle Cytoskeleton.The emerging role of alternative splicing in senescence and aging.Rare Titin (TTN) Variants in Diseases Associated with Sudden Cardiac DeathCould Modification of Titin Contribute to an Answer for Heart Failure With Preserved Ejection Fraction?Mechanisms of diastolic dysfunction in heart failure with a preserved ejection fraction: If it's not one thing it's another.Muscle-Specific Mis-Splicing and Heart Disease Exemplified by RBM20.Chronic low-intensity exercise attenuates cardiomyocyte contractile dysfunction and impaired adrenergic responsiveness in aortic-banded mini-swine.Current Perspectives on Systemic Hypertension in Heart Failure with Preserved Ejection Fraction.Prioritization of Variants Detected by Next Generation Sequencing According to the Mutation Tolerance and Mutational Architecture of the Corresponding Genes.Calcium increases titin N2A binding to F-actin and regulated thin filaments
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description
2013 nî lūn-bûn
@nan
2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
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2013年论文
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2013年论文
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name
Titin is a major human disease gene.
@ast
Titin is a major human disease gene.
@en
type
label
Titin is a major human disease gene.
@ast
Titin is a major human disease gene.
@en
prefLabel
Titin is a major human disease gene.
@ast
Titin is a major human disease gene.
@en
P2860
P1433
P1476
Titin is a major human disease gene.
@en
P2093
Henk L Granzier
Martin M LeWinter
P2860
P304
P356
10.1161/CIRCULATIONAHA.112.139717
P407
P577
2013-02-01T00:00:00Z