Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.
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Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?Present state and future perspectives of using pluripotent stem cells in toxicology researchImmunomodulatory effects of transforming growth factor-β in the liver.MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.Potential and Challenges of Induced Pluripotent Stem Cells in Liver Diseases Treatment.The Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver Diseases.Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy.Hepatic differentiation of human pluripotent stem cells in miniaturized format suitable for high-throughput screenRecent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Label-free screening assays: a strategy for finding better drug candidates.Stem cell culture engineering - process scale up and beyond.Stem cells and stem cell-derived tissues and their use in safety assessment.Competency of different cell models to predict human hepatotoxic drugs.Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.One Standardized Differentiation Procedure Robustly Generates Homogenous Hepatocyte Cultures Displaying Metabolic Diversity from a Large Panel of Human Pluripotent Stem Cells.Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening.Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes.Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactions in vitro.Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiationH3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In VitroProspects and Frontiers of Stem Cell ToxicologyHepatic differentiation of human embryonic stem cells as microscaled multilayered colonies leading to enhanced homogeneity and maturation.Dynamic regulation of EZH2 from HPSc to hepatocyte-like cell fate.Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells.Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro.Alternative Cell Sources to Adult Hepatocytes for Hepatic Cell Therapy.In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells.
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P2860
Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 04 March 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.
@en
Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.
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type
label
Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.
@en
Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.
@nl
prefLabel
Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.
@en
Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.
@nl
P2093
P2860
P50
P1433
P1476
Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening.
@en
P2093
B Kevin Park
Chris E Goldring
Cliff Rowe
Melissa A Baxter
Neil R Kitteringham
Sean Harrison
P2860
P356
10.1016/J.SCR.2010.02.002
P407
P577
2010-03-04T00:00:00Z