Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease.
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Alzheimer mechanisms and therapeutic strategiesMitochondria-associated ER membranes and Alzheimer diseaseApolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's diseaseThe dendritic hypothesis for Alzheimer's disease pathophysiology.Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapyInteractions between inflammation, sex steroids, and Alzheimer's disease risk factorsExercise, APOE genotype, and the evolution of the human lifespanSmall-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathologyApolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctorsGenetic cross-interaction between APOE and PRNP in sporadic Alzheimer's and Creutzfeldt-Jakob diseases.Metabolomic Identification in Cerebrospinal Fluid of the Effects of High Dietary Cholesterol in a Rabbit Model of Alzheimer's DiseaseGene expression profiling and association with prion-related lesions in the medulla oblongata of symptomatic natural scrapie animals.Sex modifies the APOE-related risk of developing Alzheimer diseaseEfficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: a model system to study neurotoxicity in Alzheimer's disease.APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease.A non-invasive, rapid method to genotype late-onset Alzheimer's disease-related apolipoprotein E gene polymorphismsSmall molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.Evidence that an APOE ε4 'double whammy' increases risk for Alzheimer's disease.Hilar GABAergic interneuron activity controls spatial learning and memory retrievalApolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in miceThe epigenetic dimension of Alzheimer's disease: causal, consequence, or curiosity?Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice.Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development.C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice.Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interactionPower and pitfalls of the genome-wide association study approach to identify genes for Alzheimer's disease.Imaging brain effects of APOE4 in cognitively normal individuals across the lifespan.Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling.Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice.Cerebrospinal fluid biomarkers for Alzheimer's disease: the role of apolipoprotein E genotype, age, and sex.Association of APOE with tau-tangle pathology with and without β-amyloid.11C-PiB imaging of human immunodeficiency virus-associated neurocognitive disorderDouble-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer's disease.APOE ε4 increases risk for dementia in pure synucleinopathies.Molecular events linking cholesterol to Alzheimer's disease and inclusion body myositis in a rabbit model.Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortexApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease.Apolipoprotein e sets the stage: response to injury triggers neuropathology.
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P2860
Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 27 May 2010
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease.
@en
Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease.
@nl
type
label
Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease.
@en
Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease.
@nl
prefLabel
Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease.
@en
Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease.
@nl
P1476
Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease.
@en
P2093
Yadong Huang
P304
P356
10.1016/J.MOLMED.2010.04.004
P577
2010-05-27T00:00:00Z