Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. - Wikidata - awgldk - TriplyDB

Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.

Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.

http://www.wikidata.org/entity/Q30497417

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Interactions of metals and Apolipoprotein E in Alzheimer's disease Alzheimer mechanisms and therapeutic strategies Arf4 determines dentate gyrus-mediated pattern separation by regulating dendritic spine development Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders The amyloid hypothesis of Alzheimer's disease at 25 years Antisense oligonucleotides: treating neurodegeneration at the level of RNA Proteolytic cleavage of apolipoprotein E4 as the keystone for the heightened risk associated with Alzheimer's disease Molecular aspects of age-related cognitive decline: the role of GABA signaling The dendritic hypothesis for Alzheimer's disease pathophysiology.Interneuron Progenitor Transplantation to Treat CNS Dysfunction Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students Stem cell therapy for Alzheimer's disease and related disorders: current status and future perspectives Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.Potential of GABA-ergic cell therapy for schizophrenia, neuropathic pain, and Alzheimer's and Parkinson's diseases.The reemergence of long-term potentiation in aged Alzheimer's disease mouse model.Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments.Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.Seizure resistance without parkinsonism in aged mice after tau reduction Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples Ginseng Rb fraction protects glia, neurons and cognitive function in a rat model of neurodegeneration Inhibitory interneuron progenitor transplantation restores normal learning and memory in ApoE4 knock-in mice without or with Aβ accumulation Efficient derivation of cortical glutamatergic neurons from human pluripotent stem cells: a model system to study neurotoxicity in Alzheimer's disease.APOE and neuroenergetics: an emerging paradigm in Alzheimer's disease.Pancreatic polypeptide inhibits somatostatin secretion.Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease Hilar GABAergic interneuron activity controls spatial learning and memory retrieval Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice A double-blind, placebo-controlled intervention trial of 3 and 10 mg sublingual melatonin for post-concussion syndrome in youths (PLAYGAME): study protocol for a randomized controlled trial Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice.Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice.Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development.C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice.Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons.Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice.Apolipoprotein E, gender, and Alzheimer's disease: an overlooked, but potent and promising interaction Tau reduction prevents disease in a mouse model of Dravet syndrome

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Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.

http://www.wikidata.org/entity/Q30497417

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2010 nî lūn-bûn

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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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JNEUROSCI.4040-10.2010

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Aubrey Bernardo

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Daniel Zwilling

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Gang Li

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Ligong Chen

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Nga Bien-Ly

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Qin Xu

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Seo Yeon Yoon

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Yadong Huang

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Yaisa Andrews-Zwilling

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P2860

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

Apolipoprotein E receptors in the nervous system

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1)

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13707-13717

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