The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation.
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Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomesSphingolipid signaling in metabolic disordersAdvances and New Concepts in Alcohol-Induced Organelle Stress, Unfolded Protein Responses and Organ DamageSphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophagesInhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levelsCeramide synthesis regulates T cell activity and GVHD development.Matrix-assisted laser desorption ionization imaging mass spectrometry in lipidomics.A high-throughput sphingomyelinase assay using natural substrate.Sphingolipids and ceramides of mouse aqueous humor: Comparative profiles from normotensive and hypertensive DBA/2J mice.Heat shock protein 70.1 (Hsp70.1) affects neuronal cell fate by regulating lysosomal acid sphingomyelinase.Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activityN-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative function.Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppressionRegulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.Ceramides as modulators of cellular and whole-body metabolismTriangulated mal-signaling in Alzheimer's disease: roles of neurotoxic ceramides, ER stress, and insulin resistance reviewedIn situ synthesis of fluorescent membrane lipids (ceramides) using click chemistry.Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain.Temporal aspects of the action of ASA404 (vadimezan; DMXAA).Mass spectrometry images acylcarnitines, phosphatidylcholines, and sphingomyelin in MDA-MB-231 breast tumor models.Lipid metabolism in Trypanosoma bruceiAcid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages.Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalizationA comparison of trabecular meshwork sphingolipids and ceramides of ocular normotensive and hypertensive states of DBA/2J miceDietary lipids from an evolutionary perspective: sources, structures and functions.Anti-apoptotic and anti-oxidative mechanisms of minocycline against sphingomyelinase/ceramide neurotoxicity: implication in Alzheimer's disease and cerebral ischemia.Sphingosine 1-phosphate axis: a new leader actor in skeletal muscle biology.Targeting the lysosome in cancer.Ceramide formation mediated by acid sphingomyelinase facilitates endosomal escape of caliciviruses.Targeting ceramide metabolism in obesity.Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent manner.Microcystin-LR induces ceramide to regulate PP2A and destabilize cytoskeleton in HEK293 cells.Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection.Keratin impact on PKCδ- and ASMase-mediated regulation of hepatocyte lipid raft size - implication for FasR-associated apoptosis.Acid sphingomyelinase mediates human CD4+ T-cell signaling: potential roles in T-cell responses and diseases.Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet.Sphingomyelinase-like phosphodiesterase 3b mediates radiation-induced damage of renal podocytes.Abnormal Sphingolipid World in Inflammation Specific for Lysosomal Storage Diseases and Skin Disorders.The endothelium in hypoxic pulmonary vasoconstriction.
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The acid sphingomyelinase/ceramide pathway: biomedical significance and mechanisms of regulation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The acid sphingomyelinase/cera ...... and mechanisms of regulation.
@en
The acid sphingomyelinase/cera ...... and mechanisms of regulation.
@nl
type
label
The acid sphingomyelinase/cera ...... and mechanisms of regulation.
@en
The acid sphingomyelinase/cera ...... and mechanisms of regulation.
@nl
prefLabel
The acid sphingomyelinase/cera ...... and mechanisms of regulation.
@en
The acid sphingomyelinase/cera ...... and mechanisms of regulation.
@nl
P1476
The acid sphingomyelinase/cera ...... and mechanisms of regulation.
@en
P2093
P304
P356
10.2174/156652410791608225
P577
2010-07-01T00:00:00Z