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Engineering of an isolated p110α subunit of PI3Kα permits crystallization and provides a platform for structure-based drug designSignaling by the phosphoinositide 3-kinase family in immune cellsHot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS.Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatmentIn-depth molecular profiling of the biphasic components of uterine carcinosarcomas.Assessing the subcellular distribution of oncogenic phosphoinositide 3-kinase using microinjection into live cells.Capitalizing on tumor genotyping: towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase.Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer.Addition of N-terminal peptide sequences activates the oncogenic and signaling potentials of the catalytic subunit p110α of phosphoinositide-3-kinasePIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Structural effects of oncogenic PI3Kα mutations.
@en
Structural effects of oncogenic PI3Kα mutations.
@nl
type
label
Structural effects of oncogenic PI3Kα mutations.
@en
Structural effects of oncogenic PI3Kα mutations.
@nl
prefLabel
Structural effects of oncogenic PI3Kα mutations.
@en
Structural effects of oncogenic PI3Kα mutations.
@nl
P2093
P2860
P356
P1476
Structural effects of oncogenic PI3Kα mutations.
@en
P2093
Diana Mandelker
L Mario Amzel
Oleg Schmidt-Kittler
Sandra B Gabelli
P2860
P356
10.1007/82_2010_53
P577
2010-01-01T00:00:00Z