MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin.
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Feedback Regulation of Kinase Signaling Pathways by AREs and GREsStructure of the β-form of human MK2 in complex with the non-selective kinase inhibitor TEI-L03090p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytesContrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies.The p38 pathway regulates oxidative stress tolerance by phosphorylation of mitochondrial protein IscUCrucial roles of the protein kinases MK2 and MK3 in a mouse model of glomerulonephritis.Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM.The RNA-binding protein HuR stabilizes cytosolic phospholipase A2α mRNA under interleukin-1β treatment in non-small cell lung cancer A549 CellsTNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation.Negative Feed-forward Control of Tumor Necrosis Factor (TNF) by Tristetraprolin (ZFP36) Is Limited by the Mitogen-activated Protein Kinase Phosphatase, Dual-specificity Phosphatase 1 (DUSP1): IMPLICATIONS FOR REGULATION BY GLUCOCORTICOIDS.Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumoniaThe MK2/HuR signaling pathway regulates TNF-α-induced ICAM-1 expression by promoting the stabilization of ICAM-1 mRNATreatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin SensitivityA functional copy-number variation in MAPKAPK2 predicts risk and prognosis of lung cancer.Interleukin-10 inhibits lipopolysaccharide-induced tumor necrosis factor-α translation through a SHIP1-dependent pathway.LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTPCoordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer.Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical TrialsMutant tristetraprolin: a potent inhibitor of malignant glioma cell growth.Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases.Tristetraprolin expression and microRNA-mediated regulation during simian immunodeficiency virus infection of the central nervous systemGlucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycleThe RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammationFANCA and FANCC modulate TLR and p38 MAPK-dependent expression of IL-1β in macrophages.Comparative phosphoproteomics reveals components of host cell invasion and post-transcriptional regulation during Francisella infection.An optimized streptavidin-binding RNA aptamer for purification of ribonucleoprotein complexes identifies novel ARE-binding proteins.Noncoding RNAs and LRRFIP1 regulate TNF expression.Sustained stabilization of Interleukin-8 mRNA in human macrophages.Post-transcriptional regulation of cytokine signaling by AU-rich and GU-rich elements.Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look.Isoeugenol destabilizes IL-8 mRNA expression in THP-1 cells through induction of the negative regulator of mRNA stability tristetraprolin.The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation.The effect of functional MAPKAPK2 copy number variation CNV-30450 on elevating nasopharyngeal carcinoma risk is modulated by EBV infection.Pharmacological and Genetic Inhibition of Downstream Targets of p38 MAPK in Experimental Nephrotic Syndrome.The role of RNA-binding protein tristetraprolin in cancer and immunity.MiR-137 inhibited inflammatory response and apoptosis after spinal cord injury via targeting of MK2.Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro.Luteolin inhibits inflammatory responses via p38/MK2/TTP-mediated mRNA stability.The Role of the p38-MNK-eIF4E Signaling Axis in TNF Production Downstream of the NOD1 Receptor.
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P2860
MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 June 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
MAPKAP kinases MK2 and MK3 in ...... horylation of tristetraprolin.
@en
MAPKAP kinases MK2 and MK3 in ...... horylation of tristetraprolin.
@nl
type
label
MAPKAP kinases MK2 and MK3 in ...... horylation of tristetraprolin.
@en
MAPKAP kinases MK2 and MK3 in ...... horylation of tristetraprolin.
@nl
prefLabel
MAPKAP kinases MK2 and MK3 in ...... horylation of tristetraprolin.
@en
MAPKAP kinases MK2 and MK3 in ...... horylation of tristetraprolin.
@nl
P50
P921
P1476
MAPKAP kinases MK2 and MK3 in ...... horylation of tristetraprolin.
@en
P2093
Edward Hitti
Jessica Schwermann
P304
P356
10.1016/J.BCP.2010.06.021
P407
P577
2010-06-23T00:00:00Z