Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases. - Wikidata - awgldk - TriplyDB

Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases.

Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases.

http://www.wikidata.org/entity/Q37769931

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Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective Using existing drugs as leads for broad spectrum anthelmintics targeting protein kinases Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction Statins and myocardial remodelling: cell and molecular pathways.ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells Leiomyoma cells in 3-dimensional cultures demonstrate an attenuated response to fasudil, a rho-kinase inhibitor, when compared to 2-dimensional cultures Diabetes and overexpression of proNGF cause retinal neurodegeneration via activation of RhoA pathway.Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction.Rho-kinase in development and heart failure: insights from genetic models Role of rho kinase in the functional and dysfunctional tonic smooth muscles.Protective Effect and Mechanism of Total Flavones from Rhododendron simsii Planch Flower on Cultured Rat Cardiomyocytes with Anoxia and Reoxygenation.Rho kinase as a therapeutic target in cardiovascular disease.The effect of simvastatin treatment on endothelial cell response to shear stress and tumor necrosis factor alpha stimulation.Simvastatin Ameliorates Matrix Stiffness-Mediated Endothelial Monolayer Disruption.Rho-GTPase and Atherosclerosis: Pleiotropic Effects of Statins Diabetes-induced increased oxidative stress in cardiomyocytes is sustained by a positive feedback loop involving Rho kinase and PKCβ2.Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction Arsenite activates NFκB through induction of C-reactive protein.Dissecting the roles of ROCK isoforms in stress-induced cell detachment.Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration.Increased Rho kinase activity in congestive heart failure.Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment.HIV-1 Tat Regulates Occludin and Aβ Transfer Receptor Expression in Brain Endothelial Cells via Rho/ROCK Signaling Pathway A combination of increased Rho kinase activity and N-terminal pro-B-type natriuretic peptide predicts worse cardiovascular outcome in patients with acute coronary syndrome Elevated rho-kinase activity as a marker indicating atherosclerosis and inflammation burden in polyvascular disease patients with concomitant coronary and peripheral arterial disease.Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil.Emerging drugs for coronary artery disease. From past achievements and current needs to clinical promises.Emerging major synaptic signaling pathways involved in intellectual disability.Fasudil and its analogs: a new powerful weapon in the long war against central nervous system disorders?Roles of Rho GTPases in leucocyte and leukaemia cell transendothelial migration Discovery and optimization of triazine derivatives as ROCK1 inhibitors: molecular docking, molecular dynamics simulations and free energy calculations.Central Angiotensin-II Increases Blood Pressure and Sympathetic Outflow via Rho Kinase Activation in Conscious Rabbits.Rho GTPases as therapeutic targets in cancer (Review).RhoA protects the mouse heart against ischemia/reperfusion injury The interaction between Shroom3 and Rho-kinase is required for neural tube morphogenesis in mice.Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice.The Rho kinase inhibitor azaindole-1 has long-acting vasodilator activity in the pulmonary vascular bed of the intact chest rat.Partial contribution of Rho-kinase inhibition to the bioactivity of Ganoderma lingzhi and its isolated compounds: insights on discovery of natural Rho-kinase inhibitors.Multi-Objective Optimization of Benzamide Derivatives as Rho Kinase Inhibitors.

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Rho-kinase inhibition: a novel therapeutic target for the treatment of cardiovascular diseases.

http://www.wikidata.org/entity/Q37769931

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 25 June 2010

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Rho-kinase inhibition: a novel ...... nt of cardiovascular diseases.

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Rho-kinase inhibition: a novel ...... nt of cardiovascular diseases.

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type

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Rho-kinase inhibition: a novel ...... nt of cardiovascular diseases.

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Rho-kinase inhibition: a novel ...... nt of cardiovascular diseases.

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prefLabel

Rho-kinase inhibition: a novel ...... nt of cardiovascular diseases.

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Rho-kinase inhibition: a novel ...... nt of cardiovascular diseases.

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J.DRUDIS.2010.06.011

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Drug Discovery Today

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Rho-kinase inhibition: a novel ...... ent of cardiovascular diseases

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Bryan P Yan

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Cheuk-Man Yu

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James K Liao

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Ming Dong

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Yat-Yin Lam

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P2860

Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24

Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase

Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta

The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization

Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase

Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor

p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice

Specificity and mechanism of action of some commonly used protein kinase inhibitors

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622-629

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scholarly article

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10.1016/J.DRUDIS.2010.06.011

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15-16

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15

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Gabriel Wai-Kwok Yip

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2010-06-25T00:00:00Z

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20601092

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cardiovascular disease

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3807099

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