Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.
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Activation and allosteric modulation of a muscarinic acetylcholine receptorDiscovery and Development of Small Molecule Allosteric Modulators of Glycoprotein Hormone ReceptorsDirect and Propagated Effects of Small Molecules on Protein-Protein Interaction NetworksThe Camerino symposium series (1978-2013): a privileged observatory of receptorology developmentDiversity and modularity of G protein-coupled receptor structuresNovel GPCR paradigms at the μ-opioid receptorMuscarinic acetylcholine receptor X-ray structures: potential implications for drug developmentG-protein-coupled receptors targeting: the allosteric approachPositive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medicationsOligomeric Structure of the Chemokine CCL5/RANTES from NMR, MS, and SAXS DataConopeptide -TIA Defines a New Allosteric Site on the Extracellular Surface of the 1B-AdrenoceptorGlucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic SuccessesIn vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependencyEffects of the dopamine D2 allosteric modulator, PAOPA, on the expression of GRK2, arrestin-3, ERK1/2, and on receptor internalizationIn Silico and In Vitro Analysis of Bacoside A Aglycones and Its Derivatives as the Constituents Responsible for the Cognitive Effects of Bacopa monnieriIdentification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors.Structure-function of the G protein-coupled receptor superfamily.Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptorDesign strategies for bivalent ligands targeting GPCRs.Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch.Crystal structures of the M1 and M4 muscarinic acetylcholine receptorsTargeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle.Allosteric transition: a comparison of two modelsA Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude)Disruption of the Na+ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor.Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator.Allosteric regulation of pathologic angiogenesis: potential application for angiogenesis-related blindness.Functionally biased modulation of A(3) adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancersSubchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome.The significance of G protein-coupled receptor crystallography for drug discovery.A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulationInvestigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonistsAllosteric interactions between δ and κ opioid receptors in peripheral sensory neuronsFunctional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.A negative allosteric modulator demonstrates biased antagonism of the follicle stimulating hormone receptor.Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor.Discovery of Small-Molecule Modulators of the Human Y4 ReceptorExploration of synthetic approaches and pharmacological evaluation of PNU-69176E and its stereoisomer as 5-HT2C receptor allosteric modulators.A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569.
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Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 15 July 2010
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.
@en
Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.
@nl
type
label
Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.
@en
Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.
@nl
prefLabel
Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.
@en
Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.
@nl
P2093
P50
P1433
P1476
Allosteric modulation of G protein-coupled receptors: a pharmacological perspective
@en
P2093
Arthur Christopoulos
Patrick M Sexton
Peter Keov
P356
10.1016/J.NEUROPHARM.2010.07.010
P577
2010-07-15T00:00:00Z