Alzheimer's secretases regulate voltage-gated sodium channels. - Wikidata - awgldk - TriplyDB

Alzheimer's secretases regulate voltage-gated sodium channels.

Alzheimer's secretases regulate voltage-gated sodium channels.

http://www.wikidata.org/entity/Q37785311

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The normal and pathologic roles of the Alzheimer's β-secretase, BACE1 A tale of two drug targets: the evolutionary history of BACE1 and BACE2 MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion Focal Scn1a knockdown induces cognitive impairment without seizures.BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease.The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond Ion channel regulation by β-secretase BACE1 - enzymatic and non-enzymatic effects beyond Alzheimer's disease.Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit.The E280A presenilin mutation reduces voltage-gated sodium channel levels in neuronal cells.Navβ2 knockdown improves cognition in APP/PS1 mice by partially inhibiting seizures and APP amyloid processing.

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Alzheimer's secretases regulate voltage-gated sodium channels.

http://www.wikidata.org/entity/Q37785311

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 15 September 2010

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

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name

Alzheimer's secretases regulate voltage-gated sodium channels.

@en

Alzheimer's secretases regulate voltage-gated sodium channels.

@nl

type

label

Alzheimer's secretases regulate voltage-gated sodium channels.

@en

Alzheimer's secretases regulate voltage-gated sodium channels.

@nl

prefLabel

Alzheimer's secretases regulate voltage-gated sodium channels.

@en

Alzheimer's secretases regulate voltage-gated sodium channels.

@nl

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P356

J.NEULET.2010.08.048

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Neuroscience Letters

P1476

Alzheimer's secretases regulate voltage-gated sodium channels.

@en

P2093

Doo Yeon Kim

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Dora M Kovacs

http://www.w3.org/2001/XMLSchema#string

Manuel T Gersbacher

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

Purification and cloning of amyloid precursor protein beta-secretase from human brain

The importance of neuritic plaques and tangles to the development and evolution of AD

Presenilins are essential for regulating neurotransmitter release

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

Contactin associates with Na+ channels and increases their functional expression

Sodium channel beta subunits: anything but auxiliary

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68-72

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scholarly article

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10.1016/J.NEULET.2010.08.048

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2

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2010-09-15T00:00:00Z

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46148439

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20817076

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Alzheimer's disease

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