The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond
about
Long noncoding RNAs and Alzheimer's diseaseStructural basis for the sheddase function of human meprin metalloproteinase at the plasma membraneProteomic Substrate Identification for Membrane Proteases in the BrainA tale of two drug targets: the evolutionary history of BACE1 and BACE2Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Knock-in of human BACE1 cleaves murine APP and reiterates Alzheimer-like phenotypesCombined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice.Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM.Amyloid-β Peptide Exacerbates the Memory Deficit Caused by Amyloid Precursor Protein Loss-of-Function in Drosophila.Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In VivoAbnormal Changes of Brain Cortical Anatomy and the Association with Plasma MicroRNA107 Level in Amnestic Mild Cognitive Impairment.Increased expression of reticulon 3 in neurons leads to reduced axonal transport of β site amyloid precursor protein-cleaving enzyme 1.A cellular model of amyloid precursor protein processing and amyloid-β peptide production.Rheb GTPase regulates β-secretase levels and amyloid β generationFuzhisan, a chinese herbal medicine, suppresses beta-secretase gene transcription via upregulation of SIRT1 expression in N2a-APP695 cells.Budding Yeast: An Ideal Backdrop for In vivo Lipid Biochemistry.Multiple e-Pharmacophore Modeling Combined with High-Throughput Virtual Screening and Docking to Identify Potential Inhibitors of β-Secretase(BACE1).Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.The neuronal membrane as a key factor in neurodegeneration.QARIP: a web server for quantitative proteomic analysis of regulated intramembrane proteolysis.Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer's Disease Pathology.Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains.BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology.Optimisation of BACE1 inhibition of tripartite structures by modification of membrane anchors, spacers and pharmacophores - development of potential agents for the treatment of Alzheimer's disease.Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment.
P2860
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P2860
The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artículo científico
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name
The Membrane-Bound Aspartyl Pr ...... Alzheimer's Disease and Beyond
@en
The Membrane-Bound Aspartyl Pr ...... lzheimer's Disease and Beyond.
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type
label
The Membrane-Bound Aspartyl Pr ...... Alzheimer's Disease and Beyond
@en
The Membrane-Bound Aspartyl Pr ...... lzheimer's Disease and Beyond.
@nl
prefLabel
The Membrane-Bound Aspartyl Pr ...... Alzheimer's Disease and Beyond
@en
The Membrane-Bound Aspartyl Pr ...... lzheimer's Disease and Beyond.
@nl
P2860
P356
P1476
The Membrane-Bound Aspartyl Pr ...... Alzheimer's Disease and Beyond
@en
P2093
Bastian Dislich
P2860
P356
10.3389/FPHYS.2012.00008
P577
2012-02-17T00:00:00Z