Ribozymes and riboswitches: modulation of RNA function by small molecules. - Wikidata - awgldk - TriplyDB

Ribozymes and riboswitches: modulation of RNA function by small molecules.

Ribozymes and riboswitches: modulation of RNA function by small molecules.

http://www.wikidata.org/entity/Q37798793

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Recent Advances in Developing Small Molecules Targeting Nucleic Acid Trying on tRNA for Size: RNase P and the T-box Riboswitch as Molecular Rulers Global analysis of riboswitches by small-angle X-ray scattering and calorimetry Molecular call and response: the physiology of bacterial small RNAs RNA quaternary structure and global symmetry Comparison of a PreQ1 Riboswitch Aptamer in Metabolite-bound and Free States with Implications for Gene Regulation Molecular sensing by the aptamer domain of the FMN riboswitch: a general model for ligand binding by conformational selection YbxF and YlxQ are bacterial homologs of L7Ae and bind K-turns but not K-loops An in vitro evolved glmS ribozyme has the wild-type fold but loses coenzyme dependence Many Activities, One Structure: Functional Plasticity of Ribozyme Folds Metabolite recognition principles and molecular mechanisms underlying riboswitch function Differential expression of small RNAs from Burkholderia thailandensis in response to varying environmental and stress conditions Use of a coenzyme by the glmS ribozyme-riboswitch suggests primordial expansion of RNA chemistry by small molecules Differences between cotranscriptional and free riboswitch folding Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation.Direct evaluation of tRNA aminoacylation status by the T-box riboswitch using tRNA-mRNA stacking and steric readout.Widespread genetic switches and toxicity resistance proteins for fluoride.Engineering and characterization of fluorogenic glycine riboswitches.Protein and RNA engineering to customize microbial molecular reporting.Less can be more: RNA-adapters may enhance coding capacity of replicators.Dramatic improvement of crystals of large RNAs by cation replacement and dehydration A high-throughput approach to identify genomic variants of bacterial metabolite producers at the single-cell level.Involvement of Enterococcus faecalis small RNAs in stress response and virulence.High-throughput mutate-map-rescue evaluates SHAPE-directed RNA structure and uncovers excited states.The yjdF riboswitch candidate regulates gene expression by binding diverse azaaromatic compounds.Computational identification of biologically functional non-hairpin GC-helices in human Argonaute mRNA.Crystallographic analysis of TPP riboswitch binding by small-molecule ligands discovered through fragment-based drug discovery approaches Single-molecule conformational dynamics of a biologically functional hydroxocobalamin riboswitch.Emerging structural themes in large RNA molecules.Single-molecule force spectroscopy of the add adenine riboswitch relates folding to regulatory mechanism Differential analogue binding by two classes of c-di-GMP riboswitches Riboswitches: discovery of drugs that target bacterial gene-regulatory RNAs.Structure and mechanism of the T-box riboswitches.RNA Structures as Mediators of Neurological Diseases and as Drug Targets.Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches Allosteric tertiary interactions preorganize the c-di-GMP riboswitch and accelerate ligand binding.Basis for ligand discrimination between ON and OFF state riboswitch conformations: the case of the SAM-I riboswitch.Evolving the L-lysine high-producing strain of Escherichia coli using a newly developed high-throughput screening method.Rapid RNA-ligand interaction analysis through high-information content conformational and stability landscapes.Recognition of the bacterial alarmone ZMP through long-distance association of two RNA subdomains.

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P2860

Ribozymes and riboswitches: modulation of RNA function by small molecules.

http://www.wikidata.org/entity/Q37798793

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

@zh-sg

2010年學術文章

@yue

2010年學術文章

@zh

2010年學術文章

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name

Ribozymes and riboswitches: modulation of RNA function by small molecules.

@en

Ribozymes and riboswitches: modulation of RNA function by small molecules.

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type

label

Ribozymes and riboswitches: modulation of RNA function by small molecules.

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Ribozymes and riboswitches: modulation of RNA function by small molecules.

@nl

prefLabel

Ribozymes and riboswitches: modulation of RNA function by small molecules.

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Ribozymes and riboswitches: modulation of RNA function by small molecules.

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Ribozymes and riboswitches: modulation of RNA function by small molecules.

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Adrian R Ferré-D'Amaré

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Jinwei Zhang

http://www.w3.org/2001/XMLSchema#string

Matthew W Lau

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P2860

Structural basis of ligand binding by a c-di-GMP riboswitch

A new principle of RNA folding based on pseudoknotting

Recognition of the bacterial second messenger cyclic diguanylate by its cognate riboswitch

Crystal structures of the SAM-III/S(MK) riboswitch reveal the SAM-dependent translation inhibition mechanism

Crystal structure of the lysine riboswitch regulatory mRNA element

Structure-guided engineering of the regioselectivity of RNA ligase ribozymes

Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase

Structural investigation of the GlmS ribozyme bound to Its catalytic cofactor

Mechanism of mRNA destabilization by the glmS ribozyme

Transition state stabilization by a catalytic RNA

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10.1021/BI1012645

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20931966

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