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Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson's disease modifier gene via interaction with coffeeThe genetics of attention deficit/hyperactivity disorder in adults, a reviewLeucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADPParkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cellsDysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibitionLRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative studyPharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.The Function of Autophagy in Neurodegenerative DiseasesPathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body diseaseGenetic basis of human circadian rhythm disordersConverging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's diseaseTwo-pore channels at the intersection of endolysosomal membrane trafficTranslation initiator EIF4G1 mutations in familial Parkinson diseasePale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of α-synucleinAtp13a2 expression in the periaqueductal gray is decreased in the Pink1 -/- rat model of Parkinson disease.Vocalization deficits in mice over-expressing alpha-synuclein, a model of pre-manifest Parkinson's disease.Ataxin-2: From RNA Control to Human Health and DiseaseOrchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson's disease.Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistributionCSF xanthine, homovanillic acid, and their ratio as biomarkers of Parkinson's disease.Natural toxins implicated in the development of Parkinson's disease.Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson's disease.Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons.Recent advances in the genetics of Parkinson's disease.Role of LRRK2 kinase dysfunction in Parkinson diseaseCooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's disease.Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation.Cerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directionsMitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism.Neurogenetics: advancing the "next-generation" of brain research.Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.Kinase drug discovery--what's next in the field?Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases.Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson's disease.RNAi medicine for the brain: progresses and challenges.Prediction of treatment outcomes in psychiatry--where do we stand ?Genetic LRRK2 models of Parkinson's disease: Dissecting the pathogenic pathway and exploring clinical applicationsAbsence of an orphan mitochondrial protein, c19orf12, causes a distinct clinical subtype of neurodegeneration with brain iron accumulation.A GCase chaperone improves motor function in a mouse model of synucleinopathy.Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Genetic analysis of pathways to Parkinson disease.
@en
Genetic analysis of pathways to Parkinson disease.
@nl
type
label
Genetic analysis of pathways to Parkinson disease.
@en
Genetic analysis of pathways to Parkinson disease.
@nl
prefLabel
Genetic analysis of pathways to Parkinson disease.
@en
Genetic analysis of pathways to Parkinson disease.
@nl
P2860
P1433
P1476
Genetic analysis of pathways to Parkinson disease.
@en
P2860
P304
P356
10.1016/J.NEURON.2010.10.014
P407
P5008
P577
2010-10-01T00:00:00Z
2010-10-21T00:00:00Z