Amyloid-independent mechanisms in Alzheimer's disease pathogenesis - Wikidata - awgldk - TriplyDB

Amyloid-independent mechanisms in Alzheimer's disease pathogenesis

Amyloid-independent mechanisms in Alzheimer's disease pathogenesis

http://www.wikidata.org/entity/Q37808579

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Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice Synapses and Alzheimer's disease Temperature and toxic Tau in Alzheimer's disease: new insights Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord Injury Precocious Alterations of Brain Oscillatory Activity in Alzheimer's Disease: A Window of Opportunity for Early Diagnosis and Treatment Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases Recent advances in the application of metabolomics to Alzheimer's Disease Alzheimer's therapeutics: translation of preclinical science to clinical drug development Cellular mechanisms of γ-secretase substrate selection, processing and toxicity HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease.AAV2/1 CD74 Gene Transfer Reduces β-amyloidosis and Improves Learning and Memory in a Mouse Model of Alzheimer's Disease.Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in Mice Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime Protective Effects of Dietary Supplementation with a Combination of Nutrients in a Transgenic Mouse Model of Alzheimer's Disease Scopolamine provocation-based pharmacological MRI model for testing procognitive agents.Imaging and cerebrospinal fluid biomarkers in the search for Alzheimer's disease mechanisms Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease.Metal and complementary molecular bioimaging in Alzheimer's disease.Smoking and increased Alzheimer's disease risk: a review of potential mechanisms Progress in Alzheimer's disease.Individual organelle pH determinations of magnetically enriched endocytic organelles via laser-induced fluorescence detection Metal imaging in neurodegenerative diseases.The effects of sesquiterpenes-rich extract of Alpinia oxyphylla Miq. on amyloid-β-induced cognitive impairment and neuronal abnormalities in the cortex and hippocampus of mice.Positive evolutionary selection of an HD motif on Alzheimer precursor protein orthologues suggests a functional role.Human cognitive function and the obesogenic environment.Early calcium dysregulation in Alzheimer's disease: setting the stage for synaptic dysfunction.Genetics of dementia.Beneficial effect of antibodies against β- secretase cleavage site of APP on Alzheimer's-like pathology in triple-transgenic mice.Integrated approaches for analyzing U1-70K cleavage in Alzheimer's disease.Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.Systematic review of the relationship between amyloid-β levels and measures of transgenic mouse cognitive deficit in Alzheimer's disease.A translational continuum of model systems for evaluating treatment strategies in Alzheimer's disease: isradipine as a candidate drug.BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aβ antibody labeling of early-onset axon terminal pathology.Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease Absence of the Cdk5 activator p35 causes adult-onset neurodegeneration in the central brain of Drosophila A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's disease in the ADNI cohort.

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P2860

Amyloid-independent mechanisms in Alzheimer's disease pathogenesis

http://www.wikidata.org/entity/Q37808579

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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2010年學術文章

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name

Amyloid-independent mechanisms in Alzheimer's disease pathogenesis

@en

Amyloid-independent mechanisms in Alzheimer's disease pathogenesis.

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type

label

Amyloid-independent mechanisms in Alzheimer's disease pathogenesis

@en

Amyloid-independent mechanisms in Alzheimer's disease pathogenesis.

@nl

prefLabel

Amyloid-independent mechanisms in Alzheimer's disease pathogenesis

@en

Amyloid-independent mechanisms in Alzheimer's disease pathogenesis.

@nl

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JNEUROSCI.4305-10.2010

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Journal of Neuroscience

P1476

Amyloid-independent mechanisms in Alzheimer's disease pathogenesis

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P2093

Jie Shen

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Li-Huei Tsai

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Nikolaos K Robakis

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Ralph A Nixon

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Sanjay W Pimplikar

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P2860

Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk

Presenilins are essential for regulating neurotransmitter release

E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction

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14946-14954

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10.1523/JNEUROSCI.4305-10.2010

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21068297

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Alzheimer's disease

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3426835

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