Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues.
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A Novel Prolyl Endopeptidase Inhibitor, JTP-4819 - Its Behavioral and Neurochemical Properties for the Treatment of Alzheimer's DiseaseAATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons.Evaluation of novel PET ligands (+)N-[11C]methyl-3-piperidyl benzilate ([11C](+)3-MPB) and its stereoisomer [11C](-)3-MPB for muscarinic cholinergic receptors in the conscious monkey brain: a PET study in comparison with.Relationship of amyloid to Alzheimer's disease.A ligand-free, soluble urokinase receptor is present in the ascitic fluid from patients with ovarian cancer.Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.RNA polymerase III drives alternative splicing of the potassium channel-interacting protein contributing to brain complexity and neurodegenerationIron and aluminum homeostasis in neural disorders.Characterization of alternative routes for processing of the Alzheimer beta/A4-amyloid precursor protein. Differential effects of phorbol esters and chloroquine.Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.A glycine site as therapeutic target.An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer's disease brain samples.Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants.Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptideAmnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease.Repression of the beta-amyloid gene in a Hox-3.1-producing cell line.Real-time investigation of cytochrome c release profiles in living neuronal cells undergoing amyloid beta oligomer-induced apoptosis.Personality and behavioural changes do not precede memory problems as possible signs of dementia in ageing people with Down syndrome.Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: Emergence of the Solution to an Important Unmet Need.Characterization of a secretase activity which releases angiotensin-converting enzyme from the membrane.Efflux of human and mouse amyloid beta proteins 1-40 and 1-42 from brain: impairment in a mouse model of Alzheimer's disease.In-vitro matured human macrophages express Alzheimer's beta A4-amyloid precursor protein indicating synthesis in microglial cells.Age differences in muscarinic cholinergic receptors assayed with (+)N-[(11)C]methyl-3-piperidyl benzilate in the brains of conscious monkeys.Microvasculature in brain biopsy specimens from patients with Alzheimer's disease: an immunohistochemical and ultrastructural study.Development of novel PET probe [¹¹C](R,R)HAPT and its stereoisomer [¹¹C](S,S)HAPT for vesicular acetylcholine transporter imaging: a PET study in conscious monkey.Alpha 2-macroglobulin synthesis in interleukin-6-stimulated human neuronal (SH-SY5Y neuroblastoma) cells. Potential significance for the processing of Alzheimer beta-amyloid precursor protein.Behavioural disturbance in people with Down's syndrome and dementia.A comparison of β-amyloid (Aβ) deposition in the medial temporal lobe in late-onset sporadic Alzheimer's disease, and Down's syndrome
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Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on June 1990
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues.
@en
Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues.
@nl
type
label
Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues.
@en
Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues.
@nl
prefLabel
Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues.
@en
Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues.
@nl
P356
P1433
P1476
Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues.
@en
P2093
P304
P356
10.1126/SCIENCE.2111582
P407
P577
1990-06-01T00:00:00Z