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Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling patExploring the Inhibitory Mechanism of Approved Selective Norepinephrine Reuptake Inhibitors and Reboxetine Enantiomers by Molecular Dynamics StudyIdentification of Aurora-A Inhibitors by Ligand and Structure-Based Virtual Screening.Integrity of p53 associated pathways determines induction of apoptosis of tumor cells resistant to Aurora-A kinase inhibitorsAurora A kinase (AURKA) in normal and pathological cell division.A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets.On the molecular mechanisms of mitotic kinase activation.A Dual Non-ATP Analogue Inhibitor of Aurora Kinases A and B, Derived from Resorcinol with a Mixed Mode of Inhibition.Bioactive compounds of Eriocaulon sieboldianum blocking proliferation and inducing apoptosis of HepG2 cells might be involved in Aurora kinase inhibition.Discovery of 7-aryl-substituted (1,5-naphthyridin-4-yl)ureas as aurora kinase inhibitors.Phosphorylation of NuMA by Aurora-A kinase in PC-3 prostate cancer cells affects proliferation, survival, and interphase NuMA localization.Specificity rendering 'hot-spots' for aurora kinase inhibitor design: the role of non-covalent interactions and conformational transitions.Identification of the inhibitory mechanism of FDA approved selective serotonin reuptake inhibitors: an insight from molecular dynamics simulation study.Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one derivatives as Aurora A kinase inhibitors: LQTA-QSAR analysis and detailed systematic validation of the developed model.Update from the 2011 International Schwannomatosis Workshop: From genetics to diagnostic criteria.3D-QSAR-assisted drug design: identification of a potent quinazoline-based Aurora kinase inhibitor.QSAR studies on imidazopyrazine derivatives as Aurora A kinase inhibitors.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 13 December 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Aurora-A kinase inhibitor scaffolds and binding modes.
@en
Aurora-A kinase inhibitor scaffolds and binding modes.
@nl
type
label
Aurora-A kinase inhibitor scaffolds and binding modes.
@en
Aurora-A kinase inhibitor scaffolds and binding modes.
@nl
prefLabel
Aurora-A kinase inhibitor scaffolds and binding modes.
@en
Aurora-A kinase inhibitor scaffolds and binding modes.
@nl
P2093
P1433
P1476
Aurora-A kinase inhibitor scaffolds and binding modes.
@en
P2093
P304
P356
10.1016/J.DRUDIS.2010.12.003
P50
P577
2010-12-13T00:00:00Z