Catalysis and mechanistic insights into sirtuin activation.
about
The role of sirtuins in cellular homeostasisInsights into Lysine Deacetylation of Natively Folded Substrate Proteins by Sirtuins.Sirtuin catalysis and regulationMetabolism as a key to histone deacetylase inhibition.Novel thiourea-based sirtuin inhibitory warheads.The sirtuin family's role in aging and age-associated pathologies.Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease.Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.Histone deacetylase activators: N-acetylthioureas serve as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate.Lysine Deacetylases Exhibit Distinct Changes in Activity Profiles Due to Fluorophore Conjugation of Substrates.Epigenetic drug discovery: breaking through the immune barrier.New synthetic approach to paullones and characterization of their SIRT1 inhibitory activity.Sirtuin Deacetylation Mechanism and Catalytic Role of the Dynamic Cofactor Binding Loop.Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay.Biophysical characterization of hit compounds for mechanism-based enzyme activation.
P2860
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P2860
Catalysis and mechanistic insights into sirtuin activation.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Catalysis and mechanistic insights into sirtuin activation.
@en
Catalysis and mechanistic insights into sirtuin activation.
@nl
type
label
Catalysis and mechanistic insights into sirtuin activation.
@en
Catalysis and mechanistic insights into sirtuin activation.
@nl
prefLabel
Catalysis and mechanistic insights into sirtuin activation.
@en
Catalysis and mechanistic insights into sirtuin activation.
@nl
P2093
P2860
P356
P1433
P1476
Catalysis and mechanistic insights into sirtuin activation.
@en
P2093
Jessica L Feldman
John M Denu
Kristin E Dittenhafer-Reed
P2860
P304
P356
10.1002/CBIC.201000434
P577
2010-11-09T00:00:00Z